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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_Igf1r_WT_KO]

ABSTRACT: Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_Igf1r_WT_KO]

PROVIDER: PRJNA967992 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24457624_1.fastq.gz	Fastqsanger.gz
	SRR24457624_2.fastq.gz	Fastqsanger.gz
	SRR24457625_1.fastq.gz	Fastqsanger.gz
	SRR24457625_2.fastq.gz	Fastqsanger.gz
	SRR24457626_1.fastq.gz	Fastqsanger.gz

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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_Igf1r_WT_KO]

Project description:The mammalian endometrium is covered by the luminal epithelium (Le), which directly interacts with the blastocyst and plays an important role in the establishment of reciprocal crosstalk between the embryo and receptive uterus during implantation. However, the effect of the blastocyst on uterine receptivity is far from well understood. Through transcriptomic profiling of the uterine Le isolated by laser capture microdissection, it was demonstrated that global gene expression changes occurred in Le between pseudopregnant mice without embryos and pregnant mice with embryos. Some differentially expressed genes, including upregulated Areg, Ihh, Lifr and downregulated Msx1, Pgr, Gata2, have been reported to regulate the establishment of uterine receptivity. Besides, we found that blastocysts induced an increase in both the number and acidification of lysosome, consistent with enhanced lysosomal hydrolase activity in uterine Le. Further exploration uncovered that blastocyst-derived IGF2 was involved into the activation of epithelial STAT3 to induce lysosomal hydrolase expression, and inhibition of lysosomal function derails normal uterine receptivity and embryo implantation. Finally, based on the proteomic data of both epithelia and the separated lysosome, it was revealed that CLDN1 and MUC1, two well-known downregulated molecules for successful implantation, are degraded by epithelial lysosome. In brief, our data demonstrated that blastocysts induced normal epithelium differentiation with lysosome activation to promote the establishment of uterine receptivity for embryo implantation.

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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_D4_PsdD4]

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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia

Project description:Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia

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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_D4_PsdD4]

Project description:Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_D4_PsdD4]

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Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia

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2024-01-10 | GSE231828 | GEO

Oligodendrocyte precursor cells facilitate neuronal lysosome release

Project description:Oligodendrocyte precursor cells (OPCs) shape brain function through complex mechanisms. We found that OPCs facilitate neuronal lysosome exocytosis by contacting neuronal somata. Reduced number or process branching of OPCs decreased these contacts, accompanied with lysosome accumulation and altered metabolism in neurons, and more senescent neurons with age. In Alzheimer's mouse models, OPC-neuron contacts were fewer, and lysosomes accumulated. Our findings are relevant for preventing aging-related pathologies and treatment of neurodegenerative diseases.

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Project description:About one week after fertilization, human embryos implant into the uterus. This necessitates the formation of a blastocyst consisting of a sphere encircling a cavity lodging the embryo proper. Stem cells can form a blastocyst model, which we termed blastoid. Here we show that naive human pluripotent stem cells (PXGL hPSCs) efficiently (>70%) form blastoids generating blastocyst-stage analogs of the 3 founding lineages (>97% trophectoderm, epiblast, and primitive endoderm) according to the sequence and to the pace of blastocyst development. Blastoids form the first axis and we observe that the epiblast induces the maturation of the polar trophectoderm that consequently acquires the specific and transient potential to attach to hormonally-stimulated endometrial cells. Such human blastoids are faithful, scalable, versatile, and ethical models to explore human implantation and development.

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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Project description:Oligodendrocyte precursor cells facilitate neuronal lysosome release

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Transcriptomic profile reveals the global remodeling of blastocyst for implantation

Project description:Implantation of the blastocyst into the uterus is a developmental milestone in mammalian embryonic development, which is the gateway for further development of fetus. At this time, remodeling of the blastocyst to an implantation competent status, which is known as blastocyst activation, is indispensable for embryo implantation.This RNA sequence data is from the Dormant, Reactivating and Reactivated blastocyst.

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