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Single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

ABSTRACT: single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

PROVIDER: PRJNA968167 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24461600_1.fastq.gz	Fastqsanger.gz
	SRR24461600_2.fastq.gz	Fastqsanger.gz
	SRR24461601_1.fastq.gz	Fastqsanger.gz
	SRR24461601_2.fastq.gz	Fastqsanger.gz
	SRR24461602_1.fastq.gz	Fastqsanger.gz

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RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

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single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

Project description:The goal of this study is to identify gene expression changes upon SON overexpression in WT and Mettl3 cKO LSK (Lin-cKit+Sca1+) cells at single cell level

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RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

Project description:RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

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mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

Project description:N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the CA1 and CA3 in the hippocampus (Nex-CreERT2 Mettl3 or Fto cKO) on the transcriptome of CA1 and CA3 as well as the transcriptomic response of the CA1 and CA3 transcriptome to fear conditioning.

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m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

Project description:N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the neocortex and hippocampus (Camk2a-Cre Mettl3 or Fto cKO) on the cortical epitranscriptome. PolyA-RNA-fragments from 3-5 replicates per group were processed both as m6A/m-sample (RNA immunoprecipiation RIP with an m6A and m6Am antibody) and RNA-input sample.

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mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

Project description:mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

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m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

Project description:m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

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Project description:Exon and expression analysis of HeLa cells after knockdown of SON Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. Our laboratory recently showed that a large SR protein called Son has unique repeat motifs that are essential for maintaining the subnuclear organization of pre-mRNA processing factors in nuclear speckles. Motif analysis of Son highlights putative RNA interaction domains that suggest a direct role for Son in pre-mRNA splicing. A genome-wide screen was performed to identify putative human transcription and splicing targets of Son.

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