Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The use of ectopic volar fibroblasts to modify skin identity II

ABSTRACT: The use of ectopic volar fibroblasts to modify skin identity II

PROVIDER: PRJNA970381 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24474208_1.fastq.gz	Fastqsanger.gz
	SRR24474208_2.fastq.gz	Fastqsanger.gz
	SRR24474209_1.fastq.gz	Fastqsanger.gz
	SRR24474209_2.fastq.gz	Fastqsanger.gz
	SRR24474210_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

The use of ectopic volar fibroblasts to modify skin identity III

Project description:The modification of skin identity, such as the conversion of residual limb/stump (non-volar) skin of amputees to pressure-resistant palmoplantar skin to enhance prosthesis use and minimize skin breakdown, has tremendous clinical potential. Recognizing the capacity of fibroblasts to modify keratinocyte differentiation, we hypothesized that volar fibroblast injections might induce ectopic volar characteristics. First, we observed pressure-responsive volar fibroblast resulting in increased limb development after pressure treatment, then we confirmed this in using a bioprinted skin construct, and later in a clinical trial that showed increased volar measures in non-volar skin after volar fibroblast injections. Bulk and single cell RNA seq demonstrate gene ontology categories of cornified envelope, keratinization and morphogenic pathways. Thus, the long-term engraftment of volar fibroblasts creates a platform for the therapeutic development

2024-09-09 | GSE231997 | GEO

The use of ectopic volar fibroblasts to modify skin identity II

2024-09-09 | GSE231996 | GEO

The use of ectopic volar fibroblasts to modify skin identity I

2024-09-09 | GSE231995 | GEO

The use of ectopic volar fibroblasts to modify skin identity

Project description:The use of ectopic volar fibroblasts to modify skin identity

| PRJNA970375 | ENA

The use of ectopic volar fibroblast to modify skin identity IV [Xenium]

2024-09-09 | GSE270437 | GEO

The use of ectopic volar fibroblasts to modify skin identity III

Project description:The use of ectopic volar fibroblasts to modify skin identity III

| PRJNA970380 | ENA

The use of ectopic volar fibroblasts to modify skin identity I

Project description:The use of ectopic volar fibroblasts to modify skin identity I

| PRJNA970379 | ENA

The use of ectopic volar fibroblast to modify skin identity IV [Xenium]

Project description:The use of ectopic volar fibroblast to modify skin identity IV [Xenium]

| PRJNA1126627 | ENA

The use of ectopic volar fibroblasts to modify skin identity.

Project description:Skin identity is controlled by intrinsic features of the epidermis and dermis and their interactions. Modifying skin identity has clinical potential, such as the conversion of residual limb and stump (nonvolar) skin of amputees to pressure-responsive palmoplantar (volar) skin to enhance prosthesis use and minimize skin breakdown. Greater keratin 9 (KRT9) expression, higher epidermal thickness, keratinocyte cytoplasmic size, collagen length, and elastin are markers of volar skin and likely contribute to volar skin resiliency. Given fibroblasts' capacity to modify keratinocyte differentiation, we hypothesized that volar fibroblasts influence these features. Bioprinted skin constructs confirmed the capacity of volar fibroblasts to induce volar keratinocyte features. A clinical trial of healthy volunteers demonstrated that injecting volar fibroblasts into nonvolar skin increased volar features that lasted up to 5 months, highlighting a potential cellular therapy.

| S-EPMC11457755 | biostudies-literature

The use of ectopic volar fibroblasts to modify skin identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-09 | GSE231998 | GEO