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Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst173_scrnaseq]

ABSTRACT: Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst173_scrnaseq]

PROVIDER: PRJNA970720 | ENA |

REPOSITORIES: ENA

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Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration

Project description:Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration

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Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration

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Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration

Project description:In contrast to adult mammals, adult zebrafish are able to fully regenerate injured cardiac tissue, and this regeneration process requires an adequate and tightly controlled immune response. However, which immune aspects drive particular aspects of the regenerative response are unclear. Here, we report the participation and requirement of the antigen presentation-adaptive immunity axis during zebrafish cardiac regeneration. We found that, in addition to immune cells, endocardial cells start expressing antigen presentation genes following the initial innate immune response. Consistent with this finding, we observed that helper T cells, a.k.a. Cd4+ T cells, are closely associated with phosphoERK+ (pERK+) (i.e., activated) endocardial cells at these stages. We inactivated major histocompatibility complex (MHC) class II antigen presentation by generating cd74a; cd74b double mutants, which display a defective immune response. In these mutants, both Cd4+ T cells and pERK+ endocardial cells fail to efficiently infiltrate the injured tissue. Notably, this model of compromised antigen presentation exhibits additional defects in cardiac regeneration including reduced cardiomyocyte dedifferentiation and proliferation. Altogether, these findings reveal a necessary role for antigen presentation during zebrafish cardiac regeneration and point to an immune crosstalk between T cells and endocardial cells, thereby further establishing a link between the adaptive immune response and tissue regeneration.

2024-03-06 | GSE230669 | GEO

Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst93_scrnaseq]

2024-03-06 | GSE232060 | GEO

Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst173_scrnaseq]

2024-03-06 | GSE232059 | GEO

Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst93_scrnaseq]

Project description:Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration [dst93_scrnaseq]

| PRJNA970725 | ENA

Antigen Presenting Dendritic Cells

Project description:Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

2004-09-30 | GSE702 | GEO

Antigen presenting cells of myeloid origin

Project description:Transcriptional profiles of four different myeloid antigen presenting cell (APC) subsets (BDCA-1+ circulating myeloid dendritic cells, CD14+ monocytes, and in vitro generated immature and mature monocyte-derived dendritic cells) were used for comprehensive transcriptome analysis. Based on the gene expression profiling data, a quantitative relationship between myeloid APC in functionally related gene spaces was established. Keywords = myeloid antigen presenting cells Keywords = dendritic cell subsets Keywords: repeat sample

2017-12-21 | GSE2215 | GEO

Interferon dependent genes of intrathymic antigen presenting cells

Project description:Interferon dependent genes of intrathymic antigen presenting cells

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Endocardial cells function as antigen-presenting cells to promote zebrafish heart regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-06 | GSE232061 | GEO