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Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (ATAC-Seq)

ABSTRACT: Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (ATAC-Seq)

PROVIDER: PRJNA970778 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24486950_1.fastq.gz	Fastqsanger.gz
	SRR24486950_2.fastq.gz	Fastqsanger.gz
	SRR24486951_1.fastq.gz	Fastqsanger.gz
	SRR24486951_2.fastq.gz	Fastqsanger.gz
	SRR24486952_1.fastq.gz	Fastqsanger.gz

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Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration

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Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (2N RNA-Seq)

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Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration

Project description:In axolotls, stem cells are systemically prompted to re-enter the cell cycle upon amputation. We sought to identify whether the proliferating cells of the systemically-activated limbs are epigenetically different from those of homeostatic limbs. identify which cells drive systemic-activation response in the limbs distant to the amputation.

2024-09-04 | GSE276204 | GEO

Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program

Project description:Identifying the genetic program that induces limb regeneration in salamanders is an important resource for regenerative medicine, which currently lacks tools to promote regeneration of functional body structures. The genetic network underlying limb regeneration has been elusive due to the complexity of the injury response that occurs concomitant to blastema formation. Here we performed parallel expression profile time courses of non-regenerative lateral wounds versus amputated limbs in axolotl. We show that limb regeneration occurs in three distinguishable phases--early wound healing followed by a transition phase leading to establishment of the limb development program. By focusing on the transition phase, we identified 93 strictly regeneration-associated genes involved in oxidative stress response, chromatin modification, epithelial development and limb development. The specific expression of the genes was confirmed by in situ hybridization. Regeneration-specific expression databases are critical resources for understanding how regeneration-relevant phenotypes can be induced from adult cells Regeneration of the axolotl forelimb lower arm was compared with the healing of a deep lateral injury in a high density timecourse (uncut, 3h, 6h, 9h, 12h, 24h, 36h, 52h, 72h, 120h, 168h, 288h and 528h after injury). Three independent biological replicates were performed using separate cluches of animals. Amputated and lateral wound samples were made as matched contralateral samples of four pooled animals per timepoint.

2013-01-01 | E-GEOD-36451 | biostudies-arrayexpress

Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program

2013-01-01 | GSE36451 | GEO

Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (ATAC-Seq)

2023-05-13 | GSE232080 | GEO

Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (4N RNA-Seq)

Project description:In axolotls, stem cells are systemically prompted to re-enter the cell cycle upon amputation. We sought to identify which cells drive systemic-activation response in the limbs distant to the amputation.

2023-05-13 | GSE232083 | GEO

Adrenergic signaling stimulates body-wide stem cell activation for limb regeneration (2N RNA-Seq)

Project description:In axolotls, stem cells are systemically prompted to re-enter the cell cycle upon amputation. We sought to identify how the cells surrounding the systemically activated cells respond to an amputation.

2023-05-13 | GSE232082 | GEO

Blastemal progenitors modulate immune signaling during early limb regeneration.

Project description:Blastema formation is a hallmark of limb regeneration that requires proliferation and migration of progenitors derived from many tissues to the amputation plane. To better understand the genetic programs that initiate limb regeneration, we reasoned that blastemal progenitors would be among early proliferating cells in the stump following amputation. Here we separately profiled dividing and non-dividing stump tissues, as well as the wound epidermis, during early axolotl limb regeneration to examine transcriptional programs of blastemal progenitors. We provide a description of the changes in gene expression specific to early dividing cells at the site of amputation, inclusive of progenitors for the regenerating limb. This work collectively demonstrates differential suppression/activation of core developmental signaling pathways in subsets of the early regenerating limb and further suggests that interleukin-8 (il-8) signaling is important for regeneration.

2019-01-01 | GSE111213 | GEO

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