Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [HotvsCold]

ABSTRACT: Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [HotvsCold]

PROVIDER: PRJNA971503 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24503754.fastq.gz	Fastqsanger.gz
	SRR24503755.fastq.gz	Fastqsanger.gz
	SRR24503756.fastq.gz	Fastqsanger.gz
	SRR24503757.fastq.gz	Fastqsanger.gz
	SRR24503758.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins

Project description:Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins

| PRJNA973597 | ENA

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [scRNAseq]

Project description:Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [scRNAseq]

| PRJNA973601 | ENA

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Liver]

Project description:Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Liver]

| PRJNA971505 | ENA

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Tumor]

Project description:Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Tumor]

| PRJNA971510 | ENA

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Liver]

Project description:We sought to understand the mechanism by which hepatocytes coordinate immune surveillance

2024-03-13 | GSE232264 | GEO

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [HotvsCold]

Project description:To define changes in the liver that coordinate systemic inflammation and T cell surveillance, we performed RNA sequencing on livers of mice with T cellhigh and T celllow tumors.

2024-03-13 | GSE232260 | GEO

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-13 | GSE232701 | GEO

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [scRNAseq]

Project description:We considered the possibility that STAT3 signaling specifically in hepatocytes may influence T cell surveillance in cancer

2024-03-13 | GSE232696 | GEO

Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Tumor]

Project description:We considered the possibility that STAT3 signaling specifically in hepatocytes may influence T cell surveillance in cancer

2024-03-13 | GSE232266 | GEO

Irisin reduces Amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

Project description:A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β protein (Aβ) in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin-domain III containing 5 (FNDC5). Here, using a three-dimensional (3D) cell culture model of AD, we show that irisin significantly reduces Aβ pathology by increasing astrocytic release of the Aβ-degrading enzyme neprilysin (NEP). This is mediated by downregulation of ERK-STAT3 signaling. Finally, we show that integrin αV/β5 acts as the irisin receptor on astrocytes required for irisin-induced release of astrocytic NEP, leading to clearance of Aβ. Our findings reveal for the first time a cellular and molecular mechanism by which exercise-induced irisin attenuates Aβ pathology, suggesting a new target pathway for therapies aimed at the prevention and treatment of AD

2023-09-08 | GSE240161 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data