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Nr2f2 deficiency in Pgr-expressing cells NR2F2 genome occupancy and the H3K4me1 histone mark uterus at gestation day 3.5

ABSTRACT: Nr2f2 deficiency in Pgr-expressing cells NR2F2 genome occupancy and the H3K4me1 histone mark uterus at gestation day 3.5

PROVIDER: PRJNA972754 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24572187.fastq.gz	Fastqsanger.gz
	SRR24572188.fastq.gz	Fastqsanger.gz
	SRR24572189.fastq.gz	Fastqsanger.gz
	SRR24572190.fastq.gz	Fastqsanger.gz
	SRR24572191_1.fastq.gz	Fastqsanger.gz

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NR2F2 genome occupancy and the H3K4me1 histone mark profile in the mouse uterus at gestation day 3.5

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Uterine transcriptomic profiles of Nr2f2 deficiency in Pgr-expressing cells at gestation day 3.5

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Genome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells

Project description:We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, known as decidualization, which is a key step toward the establishment of pregnancy. Yet a long-standing unresolved issue in uterine biology is the precise roles played by the major PGR isoforms, PGR-A and PGR-B, during decidualization in the human. Our approach, expressing PGR-A and PGR-B individually after silencing endogenous PGRs in human endometrial stromal cells (HESC), enabled the analysis of the roles of these isoforms separately as well as jointly by ChIP-seq and gene-expression analysis. In order to study the cistromes of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells, we generated primary cultures of human endometrial stromal cells expressing flag tagged PGR-A and PGR-B individually after silencing endogenous PGRs. Input DNA was used as the reference sample.

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Gene expression analysis of granulosa cells from animals that are wildtype or knockout for total PGR, PGR-A or PGR-B (RNA-seq)

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