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Uterine transcriptomic profiles of Nr2f2 deficiency in Pgr-expressing cells at gestation day 3.5

ABSTRACT: Uterine transcriptomic profiles of Nr2f2 deficiency in Pgr-expressing cells at gestation day 3.5

PROVIDER: PRJNA972758 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24572191_1.fastq.gz	Fastqsanger.gz
	SRR24572191_2.fastq.gz	Fastqsanger.gz
	SRR24572192_1.fastq.gz	Fastqsanger.gz
	SRR24572192_2.fastq.gz	Fastqsanger.gz
	SRR24572193_1.fastq.gz	Fastqsanger.gz

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Uterine transcriptomic profiles of Nr2f2 deficiency in Pgr-expressing cells at gestation day 3.5

Project description:Endometrial epithelia and stroma communicate via progesterone and estrogen signaling to prepare a receptive uterus for embryo implantation in early pregnancy. The present study determines, in early pregnancy at the prereceptive stage, the uterine gene signature of the NR2F2 transcription factor that is crucial for mediating the progesterone dependent anti-proliferative actions in the epithelia.

2023-08-03 | GSE232580 | GEO

Nr2f2 deficiency in Pgr-expressing cells NR2F2 genome occupancy and the H3K4me1 histone mark uterus at gestation day 3.5

Project description:Nr2f2 deficiency in Pgr-expressing cells NR2F2 genome occupancy and the H3K4me1 histone mark uterus at gestation day 3.5

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NR2F2 genome occupancy and the H3K4me1 histone mark profile in the mouse uterus at gestation day 3.5

Project description:NR2F2 genome occupancy and H3K4me1 histone mark profiles in the prereceptive stage of the pregnant mouse uterine specimens were documented by ChIP-seq to investigate downstream targets of the NR2F2 and candidate partner transcription regulators.

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NR2F2 genome occupancy and the H3K4me1 histone mark profile in the mouse uterus at gestation day 3.5

Project description:NR2F2 genome occupancy and the H3K4me1 histone mark profile in the mouse uterus at gestation day 3.5

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Gene expression profiling in periimplantation mouse uterine luminal epithelium

Project description:We used the microarray analysis to determine the differential gene expression profiles in mouse uterine luminal epithelium between preimplantation gestation day 3.5 and postimplantation gestation day 4.5, and investigeate the molecular mechanism of the establishment of uterine receptivity and embryo implantation. Uterine luminal epithelium (LE) is critical for the establishment of uterine receptivity during embryo implantation. Many genes are known to have differential expression in the periimplantation LE but the global profiling of the altered genes in the periimplantation LE is unknown. To fill in this knowledge gap, microarray analysis was performed in gestation day 3.5 (D3.5, preimplantation) and D4.5 (postimplantation) mouse LE from natural pregnancy. There were 382 significantly upregulated and 245 significantly downregulated genes (>2 fold, P<0.05) in the D4.5 LE. There are 6 samples. 3 for gestation day 3.5 uterine luminal epithelium, the other 3 for gestation day 4.5 uterine luminal epithelium

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Transcriptomic profiles of myometrial PGR deficient and control mouse uteri at gestation day 13

Project description:Progesterone signaling is crucial for pregnancy. To investigate the role of myometrial progesterone receptor in support of pregnancy, genome-wide gene expression profiles of pregnant uterine tissues from myometrial PGR knockout and control mice were profiled by RNAseq. The transcriptomic alterations in response to PGR loss permit identification of the underlying molecular mechanisms by which progesterone and PGR control myometrial homeostasis for pregnancy.

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Uterine flushing proteome of tammar wallaby from diapause to reactivation and late gestation

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Genome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells

Project description:We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, known as decidualization, which is a key step toward the establishment of pregnancy. Yet a long-standing unresolved issue in uterine biology is the precise roles played by the major PGR isoforms, PGR-A and PGR-B, during decidualization in the human. Our approach, expressing PGR-A and PGR-B individually after silencing endogenous PGRs in human endometrial stromal cells (HESC), enabled the analysis of the roles of these isoforms separately as well as jointly by ChIP-seq and gene-expression analysis. In order to study the cistromes of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells, we generated primary cultures of human endometrial stromal cells expressing flag tagged PGR-A and PGR-B individually after silencing endogenous PGRs. Input DNA was used as the reference sample.

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