Project description:MC38 tumors resistant to anti-PD-1 treatment (MC38-resistant) were generated through serial in vivo passaging, and global gene expression analysis was used to compare resistant and parental tumors. MC38 and MC38-resistant tumors exhibited widespread changes in global gene expression.
Project description:Parental MC38 tumor cells were transduced with the STING-N153S mutant and RNA-seq for differential gene expression analysis was performed
Project description:In this study, we used bulk RNA-seq to to comprehensively compare gene expression in wild-type and Npm1-deficient tumor cells isolated from MC38 tumor tissues.
Project description:To characterize the role of Pglyrp1 in tumor immunity, we performed bulk RNA-seq for MC38-OVA tumor infiltrating CD8+ T cells from wild type and Pglyrp1-deficient mice.
Project description:Expression profile of parental wild type non-small cell lung cancer, NCI-H460, and cancer stem cell-rich (CSC-rich) populations treated with PNAs-A15 for 6 h. Results provide the information that PNAs-A15, a peptide nucleic acid of A-repeats length 15 bp, suppressed up-regulated A-repeats containing genes in both parental wild type and CSC-rich cells.
Project description:We performed RNA sequencing on parental (WT) and Cbfb-deficient (CbfbKO) MC38 cells. Cells were generated by electroporation with Cas9-sgRNA complexes using a non-targeting sgRNA (WT) or Cbfb-targeting sgRNA (CbfbKO)
