Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1

ABSTRACT: Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1

PROVIDER: PRJNA974710 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24679875_1.fastq.gz	Fastqsanger.gz
	SRR24679875_2.fastq.gz	Fastqsanger.gz
	SRR24679876_1.fastq.gz	Fastqsanger.gz
	SRR24679876_2.fastq.gz	Fastqsanger.gz
	SRR24679877_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [scRNA-seq]

Project description:Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [scRNA-seq]

| PRJNA974712 | ENA

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [4C-seq]

Project description:Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [4C-seq]

| PRJNA974714 | ENA

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [4C-seq]

Project description:The vast majority of genetic loci associated with polygenic complex traits are located in non-coding regions of the human genome. Many of these regions exhibit high-order gene regulatory relationships and complicated linkage disequilibrium (LD) configurations, which bring challenges to accurately identify causal variants and their target genes controlling specific molecular processes or traits. We employed multiplexed single-cell CRISPR interference and activation perturbations to explore the links between cis-regulatory element (CRE) and target gene expression within tight LD in the endogenous chromatin context. We validated the prevalence of multiple causality in perfect LD (pLD) for independent expression quantitative trait locus (eQTL), and revealed fine-grained genetic effects on gene expression within pLD. These effects are difficult to decipher using conventional eQTL fine-mapping or to predict via existing computational methods. We found that nearly half of the casual CREs lack classical epigenetic markers, potentially affecting gene expression through hidden regulatory mechanisms. Integrative analysis on different types of perturbation effects suggested a high regulatory plasticity of the human genome. These findings will propel further in-depth exploration of functional genomic elements, facilitating a more comprehensive understanding of gene expression regulatory patterns and the development of complex traits.

2024-12-01 | GSE233013 | GEO

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [scRNA-seq]

2024-12-01 | GSE233012 | GEO

Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-01 | GSE233014 | GEO

Endogenous retroviral elements of CHO cells

Project description:Endogenous retroviral elements of CHO cells

| PRJEB35183 | ENA

Fine Mapping of Eight Psoriasis Susceptibility Loci

Project description:Fine Mapping of Eight Psoriasis Susceptibility Loci

| PRJNA375837 | ENA

CIDR_NCI_Validation and Fine Scale Mapping of Pancreatic Cancer Susceptibility Loci

Project description:CIDR_NCI_Validation and Fine Scale Mapping of Pancreatic Cancer Susceptibility Loci

| PRJNA214445 | ENA

Role of S. cerevisiae Hap1 in oxygen-regulation

Project description:Expression microarray experiments were performed to identify all of the aerobic and hypoxic transcripts in wild-type cells. The role of Hap1 in the regulation of transcription was examined by monitoring gene expression in hap1 deletion cells. Keywords: gene expression, strain comparison, response to hypoxic conditions

2007-07-28 | GSE8613 | GEO

Global transcriptome analysis of HAP1 cells

Project description:We analyzed the global change in transcription upon CHD3-KO and SENP1-KO compared to control HAP1 cells.

2018-08-05 | GSE111272 | GEO