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A distinct neurogenomic response to a tradeoff between social challenge and opportunity in male sticklebacks (Gasterosteus aculeatus)

ABSTRACT: A distinct neurogenomic response to a tradeoff between social challenge and opportunity in male sticklebacks (Gasterosteus aculeatus)

PROVIDER: PRJNA974843 | ENA |

REPOSITORIES: ENA

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Managing the tradeoff between reproduction and survival requires flexibility in behavior and gene regulation in threespined stickleback

Project description:Predators exert a powerful selective force, however predatoravoidance can conflict with other important activities such as attracting mates. Decisions over whether to court mates versus avoid predators are vital to fitness, yet the mechanistic underpinnings of how animals manage such tradeoffs are poorly understood. Here, we investigate flexibility of behavior and gene regulation in response to a tradeoff between avoiding predators (survival) and courting potential mates (reproduction) in threespined stickleback (Gasterosteus aculeatus). We compared behavioral and transcriptomic responses of male sticklebacks faced with a courtship opportunity and cues of a predator simultaneously to males faced with a courtship opportunity or cues of a predator alone, and found that males behaviorally compromised courtship in favor of predator avoidance when faced with a tradeoff between them. The need to manage this tradeoff elicited dynamic changes in brain gene expression, and sets of functionally-connected genes were organized into discrete modules based on co-expression. Additionally, we found that behavioral flexibility in response to tradeoffs corresponded to flexibility in gene regulatory network structure. Combined, these results uncover the coordinated response by the brain to a fundamental ecological tradeoff, providing insight into the structure and function of genetic networks underpinning how animals make fitness-influencing decisions.

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A distinct neurogenomic response to a tradeoff between social challenge and opportunity in male sticklebacks (Gasterosteus aculeatus)

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Project description:The data comes from a study, where three-spined sticklebacks (Gasterosteus aculeatus) were exposed to di-n-butyl phthalate (DBP) and 17α ethinyl-oestradiol (EE2) at nominal concentrations 35 μg/L and 40 ng/L, respectively, for four days. The aim of the study was to obtain insight into the acute transcriptional responses putatively associated with endocrine disruption. RNA samples from the testes of eight individuals fish per treatment (including solvent controls, exposed only to DMSO) were used in the microarray analysis, covering the expression of approximately 21000 genes.

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The protein profiles of washes from the body cavity of Gasterosteus aculeatus L., infected with the Schistocephalus solidus, and from the surface of the helminth

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