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Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [bulk RNA-seq]

ABSTRACT: Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [bulk RNA-seq]

PROVIDER: PRJNA974851 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24681908_1.fastq.gz	Fastqsanger.gz
	SRR24681908_2.fastq.gz	Fastqsanger.gz
	SRR24681909_1.fastq.gz	Fastqsanger.gz
	SRR24681909_2.fastq.gz	Fastqsanger.gz
	SRR24681910_1.fastq.gz	Fastqsanger.gz

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Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma.

Project description:Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma.

| PRJNA974850 | ENA

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [CITE-seq]

Project description:To elucidate how CD4 T-cells impact monocyte differentaion in pancreatic ductal adenocarcinoma

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Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [CITE-seq]

Project description:Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [CITE-seq]

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Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.

Project description:Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, by employing macrophage fate-mapping approaches and single-cell RNA sequencing, we show that monocytes give rise to most macrophage subsets in PDA. Tumor-specific CD4, but not CD8, T cells promote monocyte differentiation into MHCIIhi anti-tumor macrophages. By conditional major histocompatibility complex (MHC) class II deletion on monocyte-derived macrophages, we show that tumor antigen presentation is required for instructing monocyte differentiation into anti-tumor macrophages, promoting Th1 cells, abrogating Treg cells, and mitigating CD8 T cell exhaustion. Non-redundant IFNγ and CD40 promote MHCIIhi anti-tumor macrophages. Intratumoral monocytes adopt a pro-tumor fate indistinguishable from that of tissue-resident macrophages following loss of macrophage MHC class II or tumor-specific CD4 T cells. Thus, tumor antigen presentation by macrophages to CD4 T cells dictates TAM fate and is a major determinant of macrophage heterogeneity in cancer.

| S-EPMC10448358 | biostudies-literature

Pancreatic ductal adenocarcinoma

Project description:Pancreatic ductal adenocarcinoma

| PRJNA432344 | ENA

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [bulk RNA-seq]

Project description:The function of IFNg on macrophage MHC-II differentiation in PDA was investigated using BULK RNA sequencing.

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Gene expression in pancreatic ductal adenocarcinoma

Project description:To further develop our understanding of the gene expression signature of pancreatic ductal adenocarcinoma Gene expression signatures in macrodissected resected pancreatic ductal adenocarcinoma specimens

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Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression profiling of pancreatic adenocarcinoma and ductal adenocarcinoma cell lines.

Project description:We characterized baseline gene expression profiles for eleven human pancreatic adenocarcinoma and ductal adenocarcinoma cell lines.

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MS-based proteomic analysis of pancreatic ductal adenocarcinoma

Project description:Disease-related quantitative protein expressions of pancreatic ductal adenocarcinoma were acquired by high accuracy mass spectrometry following liquid chromatography peptide separation.

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