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Next Generation Sequencing of human trophoblast stem cells expressing a doxycycline-inducible dominant-negative MAML1 construct.

ABSTRACT: Next Generation Sequencing of human trophoblast stem cells expressing a doxycycline-inducible dominant-negative MAML1 construct.

PROVIDER: PRJNA975111 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24686205.fastq.gz	Fastqsanger.gz
	SRR24686206.fastq.gz	Fastqsanger.gz
	SRR24686207.fastq.gz	Fastqsanger.gz
	SRR24686208.fastq.gz	Fastqsanger.gz
	SRR24686209.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing of human trophoblast stem cells expressing a doxycycline-inducible dominant-negative MAML1 construct.

Project description:Mastermind-like 1 (MAML1) functions as a co-activator in the NOTCH signaling pathway. A truncated version of its wild type form, the so-called dominant-negative MAML1 (DN-MAML1) , lacks the transactivation domains that are needed for stimulation of gene expression. The aim of the study was to characterize the effects of NOTCH signaling pathway inhibition in human trophoblast stem cells (TSCs) by overexpression of DN-MAML1.

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