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Peromyscus leucopus and Mus musculus

ABSTRACT: Transcriptomes of whole blood of outbred Peromyscus leucopus and Mus musculus in response to lipopolysaccharide

PROVIDER: PRJNA975149 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24733648_1.fastq.gz	Fastqsanger.gz
	SRR24733648_2.fastq.gz	Fastqsanger.gz
	SRR24733649_1.fastq.gz	Fastqsanger.gz
	SRR24733649_2.fastq.gz	Fastqsanger.gz
	SRR24733650_1.fastq.gz	Fastqsanger.gz

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Project description:The Lyme disease spirochete Borrelia burgdorferi drives a range of acute and chronic maladies in humans and other incidental hosts infected with the pathogen. However, the primary vertebrate reservoir, Peromyscus leucopus appears spared from any symptomology following infection. This has led to a common hypothesis that P. leucopus and B. burgdorferi exist symbiotically: P. leucopus restrain their immune response against the microbe and enable the enzootic cycle while B. burgdorferi avoids causing damage to the host. While aspects of this hypothesis have been tested, the exact interactions that occur between P. leucopus and B. burgdorferi during infection remain largely unknown. Here we utilized an inbred colony of P. leucopus in order to compare B. burgdorferi (B31) fitness in these rodents to the traditional B. burgdorferi murine models—C57BL/6J and C3H/HeN Mus musculus, which develop signs of inflammation akin to human disease. We find that in contrast to our expectations, B. burgdorferi were able to reach much higher burdens in M. musculus, and that the overall kinetics of infection differed between the two rodent species. Surprisingly, we also found that P. leucopus remained infectious to larval Ixodes scapularis for a far shorter period than either M. musculus strain. In line with these observations, we found that P. leucopus does launch a modest but sustained inflammatory response against B. burgdorferi in the skin, which we hypothesize leads to reduced bacterial viability and infectivity in these hosts. These observations provide new insight into the nature of reservoir species and the B. burgdorferi enzootic cycle.

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Project description:Ixodes scapularis are an important vector for at least six tick-borne human pathogens, including the predominant North American Lyme disease spirochete Borrelia burgdorferi. The ability for these ticks to survive in nature is credited, in part, to their ability to feed on a variety of hosts without excessive activation of the vertebrate immune system. While the ability for nymphal ticks to feed on a variety of hosts has been well-documented, the host-parasite interactions between larval I. scapularis and different vertebrate hosts is relatively unexplored. Here we report on the changes in the vertebrate transcriptome present at the larval tick bite site using the natural I. scapularis host Peromyscus leucopus, a non-natural rodent host Mus musculus (BALB/c), and humans. We note substantially less evidence of inflammation in P. leucopus compared to BALB/c mice and pronounced evidence of inflammation in humans. These data suggest that larval I. scapularis may have a reduced ability to suppress host immunity in non-natural hosts and expand our overall understanding of I. scapularis feeding.

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