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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

ABSTRACT: Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

PROVIDER: PRJNA975484 | ENA |

REPOSITORIES: ENA

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

| PRJNA975479 | ENA

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

| PRJNA975481 | ENA

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

| PRJNA975482 | ENA

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

Project description:To investigate the in vivo metabolic changes during WNV infection in a mouse model, we infected mice with WNV NY99 to compare to uninfected (mock) mice. We also use two compounds targeting energetic metabolism to analysed their effects on WNV infection We then performed gene expression profiling analysis using data obtained from RNA-seq from infected vs uninfected mice and treated mice.

2023-09-27 | GSE233217 | GEO

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-27 | GSE233218 | GEO

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

2023-09-27 | GSE233216 | GEO

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

Project description:To investigate the in vivo metabolic changes during WNV infection in a mouse model, we infected mice with WNV NY99 to compare to uninfected (mock) mice. We also use two compounds targeting energetic metabolism to analyze their effects on WNV infection We then performed gene expression profiling analysis using data obtained from RNA-seq from infected vs uninfected mice and treated mice.

2023-09-27 | GSE233215 | GEO

Mouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_mRNA]

2016-02-15 | GSE77192 | GEO

Mouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_microRNA]

2016-02-21 | GSE77160 | GEO

Mouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_microRNA]

Project description:The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse cerebellum infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Mice were inoculated with WNV intracranially at a dose of 100 FFU. Infected samples were collected in quintuplet; time-matched mocks were collected in quintuplet in parallel with infected samples. Time points: 2 and 4 days post-infection. GSE77161 (WCT001) and this study (WCB001) are 1/4 of cortex and 1/2 of cerebellum from the same mice. Tissues from this experiment are matched to tissues from GSE77161 (WCT001). Infectivity (titer) and pathology are measured from cortex tissue in GSE77161 (WCT001).

2016-02-21 | E-GEOD-77160 | biostudies-arrayexpress

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