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MRNA expression in mouse oviduct and Dicer1 tumors

ABSTRACT: mRNA expression in mouse oviduct and Dicer1 tumors

PROVIDER: PRJNA976189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24735380_1.fastq.gz	Fastqsanger.gz
	SRR24735380_2.fastq.gz	Fastqsanger.gz
	SRR24735381_1.fastq.gz	Fastqsanger.gz
	SRR24735381_2.fastq.gz	Fastqsanger.gz
	SRR24735382_1.fastq.gz	Fastqsanger.gz

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mRNA expression in mouse oviduct and Dicer1 tumors

Project description:We developed a genetically engineered conditional compound heterozygous Dicer1 mouse strain that fully recapitulates the bi-allelic mutations of DICER1 in DICER1 syndrome-associated cancers. Embryonic activation of bi-allelic Dicer1 mutations, driven by the anti-Müllerian hormone receptor 2 (Amhr2)-driven Cre strain (Amhr2+/cre), drove cancer development from oviduct. mRNA sequencing was performed to compare the mRNA expression profiles between tumor and normal oviduct.

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Expression in mouse oviduct and Dicer1 tumors

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microRNA expression in mouse oviduct and Dicer1 tumors

Project description:We developed a genetically engineered conditional compound heterozygous Dicer1 mouse strain that fully recapitulates the bi-allelic mutations of DICER1 in DICER1 syndrome-associated cancers. Embryonic activation of bi-allelic Dicer1 mutations, driven by the anti-Müllerian hormone receptor 2 (Amhr2)-driven Cre strain (Amhr2+/cre), drove cancer development from oviduct. Small RNA sequencing was performed to compare the microRNA expression profiles between tumor and normal oviduct.

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microRNA expression in mouse oviduct and Dicer1 tumors

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Expression in mouse oviduct and Dicer1 tumors

Project description:This SuperSeries is composed of the SubSeries listed below.

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