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Treat diabetic retinopathy in SD rats with Luo-tong formula

ABSTRACT: Treat diabetic retinopathy in SD rats with Luo-tong formula

PROVIDER: PRJNA976664 | ENA |

REPOSITORIES: ENA

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Treat diabetic retinopathy in SD rats with Luo-tong formula

Project description:DNA methylation profiling of experimental DR model and that treated with LTF. Goal was to determine the methylated differentially expressed genes (MDEGs) in the pathogenesis of DR and the specific molecular mechanisms of LTF on regulating DNA methylation modification.

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Incipient diabetic retinopathy - Early regulation of genes

Project description:The development of diabetic retinopathy is well characterized on a histological level. Early vascular alterations involve the loss of pericytes. Earlier mechanisms leading to the phenotype of diabetic retinopathy, which involves the complete neurovascular unit, are not yet fully understood. The gene expression data presented here is derived from microarrays and gives further insights into early genetic regulation in incipient diabetic retinopathy.

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Project description:To compare the circRNA expression profile of diabetic retinopathy with that of diabetes mellitus and controls, peripheral blood mononuclear cell samples were obtained and extracted from healthy controls and diabetes mellitus patients (with or without diabetic retinopathy). CircRNA Capital Bio Technology Human CircRNA Array v2 was performed to detect circRNA expression profiles. To further check differentiate circRNA, qRT_PCR assay was performed to detect the level of 5 candidates.

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Mendelian randomization identifies FLCN expression as a mediator of diabetic retinopathy

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Putative tear fluid biomarkers of diabetic retinopathy

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Cellular and Molecular Linkage between Diabetic Nephropathy and Diabetic Retinopathy

Project description:Diabetic nephropathy and diabetic retinopathy are related. We used scRNA-seq and RNA-seq to analyze the cellular linkage between them.

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Salivary biomarkers of diabetic retinopathy, part 1

Project description:To characterize human salivary proteome and determine changes in proteins expression in different stages of diabetic retinopathy.

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Salivary biomarkers of diabetic retinopathy, part 3

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