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Severe acute respiratory syndrome coronavirus 2

ABSTRACT: HIV-Cov: The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concern

PROVIDER: PRJNA977715 | ENA |

REPOSITORIES: ENA

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Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

Project description:Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. Administration of E protein in trans reduced the stress response in cells infected with rSARS-CoV-ΔE, with respiratory syncytial virus, or treated with drugs, such as tunicamycin and thapsigarcin that elicit cell stress by different mechanisms. In addition, SARS-CoV E protein down-regulated the signaling pathway inositol-requiring enzyme 1 (IRE-1) of the unfolded protein response, but not the PKR-like ER kinase (PERK) or activating transcription factor 6 (ATF-6) pathways, and reduced cell apoptosis. Overall, the activation of the IRE-1 pathway was not able to restore cell homeostasis, and apoptosis was induced probably as a meassure to protect the host by limiting virus production and dissemination. The expression of proinflammatory cytokines was reduced in rSARS-CoV-ΔE-infected cells compared to rSARS-CoV-infected cells, suggesting that the increase in stress responses and the reduction of inflammation in the absence of the E gene contributed to the attenuation of rSARS-CoV-ΔE. We used Affymetrix microarrays (Human Genome U133 plus 2.0) to compare global gene expression between SARS-CoV-infected, mock-infected and SARS-CoV-ΔE-infected cells. For ech type of sample three hybridizations were carried-out (independent biological replicates).

2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress

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Project description:Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

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Severe acute respiratory syndrome coronavirus 2

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Project description:Genomic epidemiology of SARS-CoV-2 in a UK university to identify dynamics of transmission

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Severe acute respiratory syndrome coronavirus 2

Project description:Preparation of viral stocks for clinical isolates of the SARS-CoV-2 Omicron variants

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Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

2012-06-21 | GSE30589 | GEO

Severe acute respiratory syndrome coronavirus 2

Project description:Targeted amplicon sequencing of wastewater samples for detecting SARS-CoV-2 variants with high sensitivity and resolution

| PRJDB15905 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:Sequencing results of SARS-CoV-2 genome from saliva samples of three individuals in a intrafamilial transmission of COVID-19.

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Project description:"SARS-CoV-2 infection dynamics and genomic surveillance to detect variants in wastewater a longitudinal study in Bengaluru, India"

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