Project description:We isolated RNA from sorted common myeloid progenitor cells from wild-type fetal liver, wild-type adult bone marrow, transgenic Lin28b bone marrow, let-7b/c knock-out bone marrow, and Lin28b-deficient fetal liver and compared mRNA expression profiles.
Project description:The Notch pathway plays a critical role in regulating the proliferation and differentiation of endothelial cells during liver homeostasis, so we used EC-specific RBPj conditional knock out mice, and compared the gene expression profiles of LSECs isolated from wild type versus RBPjcKO mice.