Cenopis cana
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA980354 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Eucosma cana (hoary bell) genome assembly, ilEucCana1
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Project description:We assessed the change in hepatic transciptional pattern after treatment with SGLT-2 inhibitors canagliflozin in a mice model of diet-induced obesity. Pharmacologic inhibition of the renal sodium/glucose cotransporter-2 induces glycosuria and reduces glycemia. Given that SGLT2 inhibitors (SGLT2i) reduce mortality and CV risk in T2D, improved understanding of molecular mechanisms mediating these metabolic effects is required. Treatment of obese but nondiabetic mice with the SGLT2i canagliflozin (CANA) reduces adiposity, improves glucose tolerance despite reduced plasma insulin, increases plasma ketones, and improves plasma lipid profiles. We utilized an integrated transcriptomic-metabolomics approach to demonstrate that CANA modulates key nutrient-sensing pathways, with activation of AMPK and inhibition of mTOR, independent of insulin or glucagon sensitivity or signaling. Moreover, CANA induces transcriptional reprogramming to activate catabolic pathways, increase fatty acid oxidation, reduce hepatic steatosis and diacylglycerol content, and increase hepatic and plasma levels of FGF21. Taken together, these data demonstrate that SGLT-2 inhibition triggers a fasting-like transcriptional and metabolic paradigm.
2020-04-16 | GSE148702 | GEO
Project description:Canonical protein phosphatase 3 (Ppp3) / calcineurin signaling is central to numerous physiological processes. Here we provide evidence that calcineurin plays a pivotal role in controlling systemic energy and body weight homeostasis. Knockdown of calcineurin in Drosophila melanogaster led to a decrease in body weight, and energy stores, and increased energy expenditure. D. melanogaster piggyBac transposon insertion mutants (Thibault et al., 2004) (PBac{WH}CanA1[f01787] (Calcineurin A1) and PBac{WH}CanA-14F[f02374] (CanA at 14-F)) and the isogenic wildtype w1118 strain (BL-6326) were ordered from Exelixis Drosophila Stock Collection at Harvard Medical School.
2015-08-04 | GSE71701 | GEO
Project description:Canonical protein phosphatase 3 (Ppp3) / calcineurin signaling is central to numerous physiological processes. Here we provide evidence that calcineurin plays a pivotal role in controlling systemic energy and body weight homeostasis. Knockdown of calcineurin in Drosophila melanogaster led to a decrease in body weight, and energy stores, and increased energy expenditure. D. melanogaster piggyBac transposon insertion mutants (Thibault et al., 2004) (PBac{WH}CanA1[f01787] (Calcineurin A1) and PBac{WH}CanA-14F[f02374] (CanA at 14-F)) and the isogenic wildtype w1118 strain (BL-6326) were ordered from Exelixis Drosophila Stock Collection at Harvard Medical School. RNA was isolated from the thorax of 50 flies per sample. Whole genome tiling gene arrays were utilized to reveal distinctly deregulated gene patterns that appeared in both mutants (n=4, respectively) as compared to the WT controls (n=4).
2015-08-04 | E-GEOD-71701 | biostudies-arrayexpress