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Increased hyaluronan by naked mole-rat HAS2 improves healthspan in mice [microbiome]

ABSTRACT: Increased hyaluronan by naked mole-rat HAS2 improves healthspan in mice [microbiome]

PROVIDER: PRJNA980694 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24847723_1.fastq.gz	Fastqsanger.gz
	SRR24847723_2.fastq.gz	Fastqsanger.gz
	SRR24847724_1.fastq.gz	Fastqsanger.gz
	SRR24847724_2.fastq.gz	Fastqsanger.gz
	SRR24847725_1.fastq.gz	Fastqsanger.gz

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Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

Project description:Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat1,2. To study whether the benefits of increased HMW-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHAS2). nmrHAS2 mice showed increase in hyaluronan levels in several tissues, and lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. The transcriptome signature of nmrHAS2 mice shifted towards that of longer-lived species. The most striking change observed in nmrHAS2 mice was attenuated inflammation across multiple tissues. HMW-HA reduced inflammation via several pathways including direct immunoregulatory effect on immune cells, protection from oxidative stress, and improved gut barrier function during aging. These findings demonstrate that the longevity mechanism that evolved in the naked mole-rat can be exploited to other species, and open new avenues for using HMW-HA to improve lifespan and healthspan.

2023-08-10 | GSE234563 | GEO

Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

2023-09-08 | GSE234154 | GEO

Increased hyaluronan by naked mole-rat HAS2 improves healthspan in mice [microbiome]

2023-06-12 | GSE234286 | GEO

Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

Project description:Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

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Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

Project description:Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

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Transcriptome sequencing of naked mole rat, Heterocephalus glaber

Project description:Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat

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Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [unfractionated LY]

Project description:Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the T cell developmental landscape in Naked mole-rats and showed

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