Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mansonella ozzardi isolate:Moz-Col-239

ABSTRACT: Mansonella ozzardi isolate Moz-Col-239 from Colombia, genome sequencing.

PROVIDER: PRJNA981525 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Mansonella ozzardi isolate:Moz-Col-204

Project description:Mansonella ozzardi isolate Moz-Col-204 from Colombia, genome sequencing.

| PRJNA981522 | ENA

Mansonella ozzardi isolate:Moz-Col-220

Project description:Mansonella ozzardi isolate Moz-Col-220 from Colombia, genome sequencing.

| PRJNA981514 | ENA

Mansonella ozzardi isolate:Moz-Brazil-1

Project description:Mansonella ozzardi Genome sequencing and assembly, isolate Moz-Brazil-1

| PRJNA917722 | ENA

Mansonella ozzardi

Project description:Mansonella ozzardi overview

| PRJNA918493 | ENA

Mansonella ozzardi isolate:Moz-Venz-1

Project description:Mansonella ozzardi and endosymbiont Genome sequencing and assembly

| PRJNA917766 | ENA

Wolbachia endosymbiont of Mansonella ozzardi isolate:wMoz2

Project description:Wolbachia endosymbiont of Mansonella ozzardi - Genome sequencing and assembly

| PRJNA666672 | ENA

The genome wide mapping of H3K9 and H3K23 acetylation in Moz+/+ and Moz-/- MOZ-TIF2 AML cells

Project description:Monocytic leukemia Zinc finger protein (MOZ) is a MYST-type acetyltransferase involved in chromosomal translocation in acute myelogenous leukemia (AML) and myelodysplastic syndrome. MOZ is established as essential for hematopoiesis; however, the role of MOZ in AML has not been addressed. We propose that MOZ is critical for AML development induced by MOZ-TIF2 fusions. Moz-deficient hematopoietic stem/progenitor cells (HSPCs) expressing MOZ-TIF2 could form colonies in vitro but could not induce AML in mice. By contrast, Moz was dispensable for colony formation by HOXA9-transduced cells and AML development caused by HOXA9 and MEIS1, suggesting a specific requirement for MOZ in AML induced by MOZ/MLL-fusions. Expression of the of Meis1, but not Hoxa9, was reduced in Moz-deficient MOZ-TIF2 AML cells. AML development induced by MOZ-TIF2 was rescued by introducing Meis1 into Moz-deficient cells carrying MOZ-TIF2. Meis1 deletion impaired MOZ-TIF2-mediated AML development. Active histone modifications were also severely reduced at the Meis1 locus in Moz-deficient MOZ-TIF2 AML cells. These results suggest that endogenous MOZ is critical for MOZ-fusion-induced AML development and maintains active chromatin signatures at target gene loci.

2022-07-24 | GSE208741 | GEO

Mansonella species

Project description:Mitogenomes from Mansonella species: Mansonella perstans and Mansonella sp 'DEUX'

| PRJNA942613 | ENA

Mansonella perstans

Project description:Mansonella perstans overview

| PRJNA605276 | ENA

Mansonella perstans

Project description:Mansonella perstans sequencing data

| PRJNA605189 | ENA