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Differential Gene Expression between YTN16 Gas6 Cells and YTN16 Cells

ABSTRACT: Differential Gene Expression between YTN16 Gas6 Cells and YTN16 Cells

PROVIDER: PRJNA982042 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24886377_1.fastq.gz	Fastqsanger.gz
	SRR24886377_2.fastq.gz	Fastqsanger.gz
	SRR24886378_1.fastq.gz	Fastqsanger.gz
	SRR24886378_2.fastq.gz	Fastqsanger.gz

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Differential Gene Expression between YTN16 Gas6 Cells and YTN16 Cells

Project description:We have generated Gas6 knock-down YTN16 cells using the shRNA system to specifically target Growth arrest-specific 6 (Gas6), a gene of interest in mouse gastric cancer cells. Additionally, we aimed to determine the differences in gene expression levels between YTN16 cells and YTN16 cells with Gas6 knock-down (shGas6) through RNA-sequencing analysis.

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Differential gene expression between gastric cancer cells treated with recombinant human growth-arrest specific 6 (GAS6) protein or cultured with Cancer-associated fibroblasts (CAFs).

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Gene expression in wild type and Gas6-/- endothelial cells co-cultured with cancer cells

Project description:Endothelial cells from 3 WT and 3 Gas6-/- mice were harvested, and were co-cultured with M27 murine lung cancer cells for 48 hours. Control experiments included untreated endothelial cells, and endothelial cells co-cultured with cancer cell media.

2016-08-02 | E-MTAB-3305 | biostudies-arrayexpress

Gas6/Axl signaling activates Akt in liver cancer cells

Project description:We investigated which signaling pathways downstream of Gas6/Axl promote the invasive phenotype of liver cancer cells. Thus, we performed phospho-proteomic analysis of MR hepatocytes and those expressing Axl (MR-Axl) in the presence and absence of Gas6. Protein-clustering based on the pattern of phosphorylation across the conditions and samples revealed four clusters: phospho-sites that are upregulated dependent on Axl expression (cluster 1) or Gas6 expression (cluster 2) and phospho-sites that are downregulated dependent on Axl expression (cluster 3) or Gas6 expression (cluster 4). Functional enrichment analysis showed enrichment of protein sets associated with cellular polarity and motility depending on changes in Axl expression and Gas6 activation. Furthermore, we analyzed phospho-proteomic data to estimate the activity of kinases based on kinase-substrate interactions using PhosR. Kinase perturbation analysis indicated mammalian target of rapamycin (mTOR) as the one with the highest upregulated activity in Gas6-stimulated MR-Axl cells compared to Gas6-stimulated MR cells. Accordingly, we analyzed substrates of mTOR and found that phosphorylation of Akt1 (Ser473) was upregulated in cluster 1 and highly increased in Gas6-stimulated MR-Axl, suggesting that Akt is regulated by Axl.

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Differential gene expression between gastric cancer cells treated with recombinant human growth-arrest specific 6 (GAS6) protein or cultured with Cancer-associated fibroblasts (CAFs).

Project description:Differential gene expression between gastric cancer cells treated with recombinant human growth-arrest specific 6 (GAS6) protein or cultured with Cancer-associated fibroblasts (CAFs).

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Inactivation of Gas6/Axl signaling aggravated Microglia-Astrocyte cross regulation after spinal cord injury

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