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Effect of Sirt6 depletion on gene expression of primary human chondrocytes

ABSTRACT: Effect of Sirt6 depletion on gene expression of primary human chondrocytes

PROVIDER: PRJNA984308 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24940909_1.fastq.gz	Fastqsanger.gz
	SRR24940909_2.fastq.gz	Fastqsanger.gz
	SRR24940910_1.fastq.gz	Fastqsanger.gz
	SRR24940910_2.fastq.gz	Fastqsanger.gz
	SRR24940911_1.fastq.gz	Fastqsanger.gz

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Effect of Sirt6 depletion on gene expression of primary human chondrocytes

Project description:To define the effect of SIRT6-mediated transcriptional regulation, RNA-sequencing was conducted on primary human chondrocytes depleted of SIRT6 and compared to cells nucleofected with a scrambled siRNA control (72 hours).

2023-08-08 | GSE235082 | GEO

Effect of depletion of SIRT6 in gene expression in Nucleus pulposus cells

Project description:SIRT6 is a well known histone deactylase enzyme. Here, we report the effect of its depletion in nucleus pulposus cells from rattus norvegicus. RNA seq was performed on control and sirt6 depelted cells via lentiviral transfection method. Downstream analysis includes upregulated and downregulated signalling molecules with respect to SIRT6 depletion.

2024-10-02 | GSE276440 | GEO

Effect of depletion of Myl3 in primary chondrocytes from mice

Project description:To investigate the function of Myl3 in in primary chondrocytes, we generated Col2a1-Cre: Myl3fl/fl (Myl3-KO) conditional knockout mice.We then performed RNA sequencing analysis with primary chondrocytes from Myl3-KO or control mice.

2023-05-16 | GSE232325 | GEO

Interleukin-1β effect on primary mouse articular chondrocytes

Project description:Interleukin-1β effect on primary mouse articular chondrocytes

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Zfp36l1 overexpression/knockdown effect on primary mouse articular chondrocytes

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Effect of depletion of SIRT6 in gene expression in Nucleus pulposus cells

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Regnase-1 overexpression/knockdown effect on primary mouse articular chondrocytes

Project description:Regnase-1 overexpression/knockdown effect on primary mouse articular chondrocytes

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Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

Project description:Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

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Effect of Notch2 in chondrocytes

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RNA-seq of Runx2 cKO primary chondrocytes.

Project description:Purpose: To demonstrate Runx2's association with organizing the extracellular matrix in primary chondrocytes. Method: RNA samples were collected from primary chondrocytes of 5-day-old Col2a1-CreERT2;Runx2fl/fl and Runx2fl/fl mice, cultured with or without IL-1beta. Results: Thirty-three genes cultured without IL-1beta and 45 genes with IL-1beta were up- or down-regulated by more than 2-fold in the Runx2 knockout in primary chondrocytes. Conclusions: Genes including collagen fibers were down-regulated in Runx2 cKO primary chondrocytes.

2021-01-21 | GSE165084 | GEO

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