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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy [Human_CSF_T_cell_scRNASeq]

ABSTRACT: Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy [Human_CSF_T_cell_scRNASeq]

PROVIDER: PRJNA985623 | ENA |

REPOSITORIES: ENA

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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy

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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy

Project description:This SuperSeries is composed of the SubSeries listed below.

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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy [GFP_HI_LO_scRNASeq]

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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy [Tetramer_scRNASeq]

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Activated CD4 T cells in tuberculosis express OX40, a target for host-directed immunotherapy [Human_CSF_T_cell_scRNASeq]

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Gene expression analysis of Ox40-cre/ROSA-YFP CD4+ T cell subsets

Project description:An Ox40-cre allele was used for lineage marking of CD4 T cells. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of the majority of naive T cells. These results are consistent with a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands. Keywords: T cell population comparison. Characterization of a novel subpopulation of naive T cells. Four types of T cells were sorted from mice (naive, CD44lo, CD44hi and Treg).

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