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MiRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome

ABSTRACT: miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome

PROVIDER: PRJNA985734 | ENA |

REPOSITORIES: ENA

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miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [sequencing]

Project description:Breast cancer (BCa) is the leading cause of death by cancer in women worldwide. Early diagnosis is improving the survival of BCa patients but more sensitive and specific tools are still necessary. We propose the use of miRNAs as a biomarker alternative in BCa diagnosis. MiRNAs are small non-coding RNAs that regulate gene expression. Circulating miRNAs can be detected in body fluids. Aberrant expression of miRNAs in both tissues and fluids are linked to several pathologies. Furthermore, metabolic syndrome (MeS) is a risk factor for BCa. Molecular mechanisms underlaying this association have not been fully elucidated. The aim of this work was to identify the circulating miRNAs in plasma of BCa patients and healthy donors with or without clinical features linked to MeS. MiRNAs were isolated from plasma of woman. BCa patients (N=30) were distributed into 5 clusters, according with their BCa stage: i) stages 0 and IA, ii) stage IIA, iii) stage IIB, iv) stage IIIA, and v) stages IIIB, IIIC and IV. Healthy women (HD) (N=36) were recruited and divided in two groups, control or MeS-linked disease (MeSL) when presented two or more of these conditions: BMI≥25.00 kg/m2, waist diameter≥82 cm or high blood pressure (systolic≥120, diastolic≥ 80). We hybridized miRNAs of each group using GeneChip® miRNA 4.0 Array (Affymetrix). miRNA expression profile was also determined by miRNA sequencing from 6 BC patients and 4 HD. Data analysis revealed 11 miRNAs upregulated in the plasma from BCa patients compared to HD. Meanwhile, 24 miRNAs were altered in plasma of women with MeSL compared to control.

2024-08-31 | GSE235354 | GEO

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [array]

2024-08-31 | GSE235353 | GEO

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [sequencing]

Project description:miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [sequencing]

| PRJNA985737 | ENA

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [array]

Project description:miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [array]

| PRJNA985738 | ENA

Plasma microRNA interpersonal variability in healthy individuals, pregnant women, and an individual with a stably-altered neuroendocrine phenotype

Project description:Large cohort: exRNA composition of platelet-depleted plasma from a cohort of 173 female and 63 male healthy volunteers of diverse races and ages, collected at two visits spaced two weeks apart; 4 formerly-collected aliquots from study subject P12, who displayed a stable neuroendocrine miRNA signature in plasma; 20 plasma samples of pregnant women spanning all trimesters T1 to T3 of pregnancy, with an expected placenta miRNA contribution. P12 Family: exRNA from two replicates of platelet-depleted plasma from three unstudied P12 family members and a sample from P12 collected four years after the initial discovery of the phenotype, along with samples of two healthy volunteers. Plasma subfractions: exRNA of samples from P12 and his family, two healthy male volunteers, two non-pregnant, and nine pregnant women, separated by differential ultracentrifugation into 10,000 × g and 100,000 × g pellets, and corresponding 10,000 × g and 100,000 × g supernatants.

2024-08-10 | GSE181810 | GEO

microRNAs expression Profiles in plasma from spinal tuberculosis patients and healthy volunteers

Project description:The differential expression of plasma miRNAs was analyzed in spinal tuberculosis patients and healthy volunteers using the Exiqon miRNA PCR array platform.

2023-02-23 | GSE225679 | GEO

Plasma microRNA profiles in women with and without endometriosis at different menstrual cycle phases

Project description:The objectives of the study: 1. Does the phase of the menstrual cycle alter microRNA (miRNA) plasma profiles in healthy women of reproductive age and in women with endometriosis? 2. Does this alter prospects for development of a miRNA-based diagnostic test for endometriosis? Prospectively recruited asymptomatic control women and women with surgically diagnosed endometriosis (n = 8 in each group) were included. Each patient provided blood samples in the early proliferative, late proliferative and mid luteal phases of the menstrual cycle (n = 47 total plasma samples). The cycle phase was verified by hormonal profile. RNA was extracted from each sample and expression of microRNAs was assessed using TaqMan Low Density Human miRNA arrays.

2013-05-09 | E-GEOD-46735 | biostudies-arrayexpress

Detection of plant microRNAs in EVOO and plasma samples of healthy volunteers 2 hours postingestion of 40 mL of EVOO.

Project description:NGS has been applied to microRNA-enriched RNA obtained from Extra Virgin Olive Oil (EVOO), beer and plasma samples of healthy volunteers that usually consume EVOO hours after the ingestion of 40 mL of EVOO. Results: We did not detect significant amount of microRNA in the EVOO samples. Plasma samples did not contain EVOO microRNAs nor other microRNAs from plant origin. Starting plant material was 30 mL of EVOO or a pool of plasma samples of 5 volunteers

2016-06-30 | E-GEOD-76735 | biostudies-arrayexpress

Plasma microRNA profiles in women with and without endometriosis at different menstrual cycle phases

2013-05-09 | GSE46735 | GEO

Transcription profiling of human proximal tubular epithelial cells inclubated with 5% plasma from septic patients or healthy volunteers

Project description:proximal tubular epithelial cell apoptosis were incubated with 5% plasma of septic patients or healthy volunteers diluited in RPMI 1640

2008-03-15 | E-MEXP-1510 | biostudies-arrayexpress

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