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Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium

ABSTRACT: Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium

PROVIDER: PRJNA986001 | ENA |

REPOSITORIES: ENA

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Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [RNA-seq]

Project description:Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [RNA-seq]

| PRJNA986005 | ENA

Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [ChIP-seq]

Project description:Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [ChIP-seq]

| PRJNA986006 | ENA

Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [RNA-seq]

Project description:Plasmodium berghei transcriptomes of wild-type ANKA (WT) and garid knockout parasites [garid(-)] were analyzed at the gametocyte stage.

2023-06-30 | GSE235411 | GEO

Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium [ChIP-seq]

Project description:To investigate the genome-wide binding sites of gARID in gametocytes of Plasmodium berghei, the chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) analyses were performed. Parasites expressing GFP-fused gARID were harvested after treating the infected mice with sulfadiazine and subjected to ChIP-seq experiments using anti-GFP antibody. Binding sites of gARID were determined from the sequence data.

2023-06-30 | GSE235409 | GEO

Plasmodium yoelii gender-specific gametocyte transcriptome

Project description:Plasmodium yoelii gender-specific gametocyte transcriptome

| PRJNA923669 | ENA

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

Project description:The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological changes from commitment to maturity, directed by an equally extensive control program. Several interconnected mechanisms governing sexual commitment have been described. However, the processes that drive the subsequent differentiation and development of the gametocyte remain largely unexplored. Using chromatin immunoprecipitation followed by high-throughput sequencing we map the genome-wide occupancy of H3K36me2 and H3K36me3 during early gametocyte development and describe an association between these histone modifications and the global changes in the transcriptional program driving gametocyte development post-commitment.

2021-04-20 | GSE163432 | GEO

Plasmodium falciparum PfAP2-G2 KO gametocyte microarray timecourse

Project description:Differentiation from asexual blood stages to sexual gametocytes is required for transmission of malaria parasites from the human to the mosquito host. Preventing gametocyte commitment and development would block parasite transmission, but the underlying molecular mechanisms behind these processes remain poorly understood. Here, we report that the ApiAP2 transcription factor, PfAP2-G2 (PF3D7_1408200) plays a critical role in the maturation of Plasmodium falciparum gametocytes. PfAP2-G2 binds to the promoters of a wide array of genes that are expressed at many stages of the parasite life cycle. Interestingly, we also find binding of PfAP2-G2 within the gene body of almost 3000 genes, which strongly correlates with the location of H3K36me3 and several other histone modifications as well as Heterochromatin Protein 1 (HP1), suggesting that occupancy of PfAP2-G2 in gene bodies may serve as an alternative regulatory mechanism. Disruption of pfap2-g2 does not impact asexual development, parasite multiplication rate, or commitment to sexual development but the majority of sexual parasites are unable to mature beyond stage III gametocytes. The absence of pfap2-g2 leads to overexpression of 28% of the genes bound by PfAP2-G2 and none of the PfAP2-g2 bound are downregulated, suggesting that it is a repressor. We also find that PfAP2-G2 interacts with chromatin remodeling proteins, a microrchidia (MORC) protein, and another ApiAP2 protein (PF3D7_1139300). Overall our data demonstrate that PfAP2-G2 is an important transcription factor that establishes an essential gametocyte maturation program in association with other chromatin-related proteins.

2021-02-01 | GSE160924 | GEO

Chromatin remodeling events associated with gARID are essential for gametocyte development in Plasmodium

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-30 | GSE235412 | GEO

Plasmodium falciparum PfAP2-G2 KO gametocyte microarray timecourse

Project description:Plasmodium falciparum PfAP2-G2 KO gametocyte microarray timecourse

| PRJNA674850 | ENA

Plasmodium berghei Gametocytogenesis

Project description:Transcriptional profiling of gametocyte non-producer lines in Plasmodium berghei Transcriptome of gametocyte non producer lines (natural and genetic KO) and parental (820) lines. The aim of the study was to identify key genes involved in the decision to commit to gametocytogenesis in Plasmodium berghei. These microarrays compare naturally selected lines that do not produce gametocytes, and the parental line and additionally a genetic knock out of AP2-G PBANKA_143750. Data published Sinha, Hughes, et, al Nature tbc. 2- colour microarray comparing to common background pool (containing all life cycle stages). Replicates of different life cycle stages of gametocyte non-producer lines and wild tye (WT) parental control lines

2013-12-13 | E-GEOD-53246 | biostudies-arrayexpress

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