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Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 [SiHa]

ABSTRACT: Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 [SiHa]

PROVIDER: PRJNA986107 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24982144_1.fastq.gz	Fastqsanger.gz
	SRR24982144_2.fastq.gz	Fastqsanger.gz
	SRR24982145_1.fastq.gz	Fastqsanger.gz
	SRR24982145_2.fastq.gz	Fastqsanger.gz
	SRR24982146_1.fastq.gz	Fastqsanger.gz

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Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 [SiHa]

Project description:Cisplatin resistance remains a major obstacle limiting the effectiveness of chemotherapy in cervical cancer. However, the underlying mechanism of cisplatin resistance is still unclear.

2023-08-08 | GSE235466 | GEO

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

Project description:Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

| PRJNA985752 | ENA

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

2023-08-08 | GSE235366 | GEO

RNA-Seq of H8, SiHa and KD HSPA9 SiHa cells

Project description:To investigate the different gens expression in the cervical immortalized cervical cells (H8 cells), cervical cancer cells (SiHa cells) and KD HSPA9 SiHa cells.

2023-06-25 | GSE235550 | GEO

ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

Project description:Based on the specificity with which the unique KH structural domains of hnRNP E1 bind with RNA/DNA, considering that HPV16 provides RNA/DNA binding sites, we hypothesized that hnRNP E1 may be crucial to HPV16 oncogenes expression and cervical carcinogenesis. Based on the main purpose of this study was to explore the role of hnRNP E1 on the regulation of HPV16 oncogene expression in cervical cancerization, we conducted ChIP-seq in the untreated SiHa cell line.

2022-06-16 | GSE203023 | GEO

miRNA expression profiles among SiHa, SiHa-tw2 and SiHa-shtw2

Project description:To further identify the most significantly changed miRNA resulting from the different expression levels of TWIST2 in cervical cancer cells, we used a miRNA microarray to identify the miRNA expression profiles among SiHa, SiHa-tw2 and SiHa-shtw2. The significantly deregulated miRNAs (changes of more than 2-fold in expression) included miR-23b-5p, miR-221-3p, miR-502-3p, miR-221-5p, miR-15a-5p, miR-1227, miR-93-5p and miR-4257.

2017-11-21 | GSE102706 | GEO

Transcriptome analysis of SiHa cells

Project description:This study assessed the transcriptional profile of SiHa cells. SiHa is a cervical cancer cell line with integrated HPV16, and was used as a model to study human gene expression in the context of integrated virus. Gene expression in SiHa, calculated by Cufflinks, was scored in windows around the locations of known viral integrations in patients or cell lines to determine if there was an association between gene expression and viral integration. We found that SiHa gene expression was higher near loci of integration for HPV18 vs. HPV16, cervical tissues vs. head and neck cancers, and cervical cancers vs. in vitro integrations. This study provides insight into the factors that may influence where viruses integrate in the human genome.

2015-11-30 | GSE67115 | GEO

Effects of SHetA2 on SiHa and C-33 A human cervical cancer cell lines

Project description:The objective was to identify how cervical cancer cells respond to treatment with the investigational new agent, Sulfur Heteroartoinoid A2 (SHetA2, NSC 726189) by identify proteins that are detected at significantly different levels in SHetA2-treated compared to untreated control cultures. Triplicate cultures of SiHa and C-33 A human cervical cancer cell lines were treated with 10 micromolar SHetA2 or the same volume of dimethylsulfoxide solvent (untreated controls) for 24 hours. Proteins were extracted from the cultures using M-PER (ThermoFisher).

2023-08-29 | PXD029537 | Pride

ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

Project description:ChIP-Seq hnRNP E1, Cervical cancer SiHa cells

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Microarray expression profile of circular RNAs in cervical cancer

Project description:Human immortal cervical cell line H8, human cervical cancer cell line SiHa and SiHa transfected with Wnt11-overexpression vector were included in the study. We identified circRNAs differentially expressed between H8 and SiHa or between SiHa and SiHa transfected with OV-Wnt11.

2020-03-25 | GSE147483 | GEO

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