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Transcriptomic profiling of differentially expressed mRNA, lncRNA and circRNA in lean and obese individuals

ABSTRACT: Transcriptomic profiling of differentially expressed mRNA, lncRNA and circRNA in lean and obese individuals

PROVIDER: PRJNA986916 | ENA |

REPOSITORIES: ENA

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Transcriptomic profiling of differentially expressed mRNA, lncRNA and circRNA in lean and obese individuals

Project description:Fat accumulation is the main manifestation of obesity. Obesity forms the largest fat pool because white adipocytes primarily store energy, whereas larger adipocytes may encounter hypoxia and mechanical stress and have higher levels of inflammatory cytokines and lipolysis release. In this study, we performed high-throughput sequencing to analyze the differentially expressed circRNAs in visceral adipose tissue between lean and obese individuals, and searched for the important mechanisms involved in the regulation of adipogenesis

2023-09-13 | GSE235696 | GEO

Transcription profiling of human cumulus cells in vitro isolated from polycystic ovary syndrome lean and obese individuals reveals PCOS in lean and obese individuals is associated with different molecular pathways

Project description:Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. Control) and BMI (Obese vs. Lean). Results: Two differential PCOS gene expression profiles were established: Lean-Type was formed by comparing PCOS lean (PL) vs. non-PCOS lean (NL) individuals; Obese-Type was formed by comparing PCOS obese (PO) vs. non-PCOS (NO) obese patients. Conclusions: Different molecular pathways are associated with PCOS in Lean and Obese individuals, as demonstrated by gene expression profiling of cumulus cells. Our findings provide insights into the molecular pathogenesis of PCOS. We used microarrays to study the gene expression of human cultured cumulus cells. We compared the genes expression of lean PCOS, Obese PCOS, lean controls and obese controls. Different molecular pathways are associated with PCOS in Lean and Obese patients. Experiment Overall Design: Cumulus cells obtained from woman undergoing IVF/ICSI. Following oocyte retrieval, cumulus cells were stripped from the oocyte, in preparation for the ICSI process, with a micropipette. After 48h in culture the cumulus cells were collected for RNA extraction and hybridization on Affymetrix microarrays. We compered the expression profile of 4 groups - lean PCOS, obese PCOS, lean controls and obese controls.

2008-06-11 | E-GEOD-10946 | biostudies-arrayexpress

Evaluation of transcriptomic regulations behind metabolic syndrome in obese and lean subjects

Project description:The study aimed to investigate molecular signatures in peripheral blood of individuals affected by metabolic syndrome (MetS) and different degrees of obesity. Metabolic health of 1204 individuals was assessed, and 32 subjects were recruited to four study groups: MetS lean, MetS obese, “healthy obese” and healthy lean. Whole-blood transcriptome next generation sequencing with functional data analysis was carried out.

2020-02-18 | GSE145412 | GEO

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients

2008-03-27 | GSE10946 | GEO

Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals

Project description:Raw files corresponding to the epilipidomic dataset for identification and relative quantification of oxidized complex lipids in the blood plasma of lean and obese individuals.

2021-12-23 | MSV000088608 | MassIVE

Transcriptome analysis of Epicardial Adipose Tissue from obese, diabetic and lean individulas

Project description:The overall goal of this studyis to compare the transcription differences of epicardial adipose tissue between between lean and obese and Type 2 diabetic individuals

2021-07-30 | GSE179455 | GEO

Whole blood expression profiling of obese diet-sensitive, obese diet-resistant and lean human subjects

Project description:We have carried out whole-genome expression profiling of whole blood from obese subjects, defined as obese diet-sensitive and obese diet-resistant, and well matched lean individuals. The diet-sensitive or diet-resistant status refers to the different rates of weight loss observed in the two groups on a low-calorie diet regimen. Bioinformatic analysis revealed alterations in transcription in key pathways that are consistent with impaired capacity for fatty acid oxidation driven mitochondrial ATP synthesis in obese subjects who are resistant to weight loss. A total of 80 samples are analyzed. This consists of 20 lean subjects studied at one timepoint and 20 obese subjects (10 diet-sensitive and 10 diet-resistant) studied at 3 timepoints during caloric restriction (day of entry into program, week 3 into the program and week 6 into the program)

2009-11-04 | E-GEOD-18897 | biostudies-arrayexpress

Adipose derived stem cells (ASCs) methylation differences between lean and obese individuals

Project description:Adipose derived stem cells (ASCs) methylation differences between lean and obese individuals

| PRJNA437619 | ENA

Whole blood expression profiling of obese diet-sensitive, obese diet-resistant and lean human subjects

2009-11-05 | GSE18897 | GEO

Examination of human adipose celltypes in lean and obese donors

Project description:We did single cell RNA sequencing on three lean and three obese donors. For each donor, we sorted CD45 positive and CD45 negative cells and prepared 10X scRNA-seq libaries. We observed cell type compositon changes and expression changes in the lean and obese donors.

2021-03-09 | GSE155960 | GEO

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