Project description:Gene expression in blood of children with autism spectrum disorder (ASD) was studied. Transcriptional profiles were compared with age and gender matched, typically developing children from the general population (GP) or IQ matched children with mental retardation or developmental delay (MR/DD). Experiment Overall Design: Transcriptional profiles were compared with age and gender matched, typically developing children from the general population (GP) or IQ matched children with mental retardation or developmental delay (MR/DD)

2008-10-18 | E-GEOD-6575 | biostudies-arrayexpress

Homo sapiens

Project description:A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis

| PRJNA347850 | ENA

Immune Gene Expression in Monocytes from Autism Spectrum Disorders

Project description:To examine how activation of different toll-like receptors (TLR) impacts gene expression in Autism Spectrum Disorder (ASD), we cultured peripheral blood monocytes from children with ASD, Pervasive Developmental Disorder Not Otherwise Specified (PDDNOS) or Asperger and typically developing children and treated them with either lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to activate LTR2 or 4 respectively. Following 24 hours of stimulation, we then performed RNA sequencing to profile mRNA responses between non-treated (NT), LTA and LPS treated samples for each diagnosis (control or ASD).

2021-12-17 | GSE140702 | GEO

Project description:16S rRNA gene sequence of autism spectrum disorder children

| PRJNA624252 | ENA

Homo sapiens

Project description:Blood gene expression signatures distinguish autism spectrum disorders from controls

| PRJNA119451 | ENA

Autism-associated gene expression signatures in peripheral blood leucocytes

Project description:Using DNA microarray as a global approach to understanding the molecular basis of autism, we examined gene expression profiling in peripheral blood from 21 young adults with autism spectrum disorder (ASD) and healthy mothers having children with ASD, between whom there was no blood relationship. Several genes which were significantly changed in the ASD group comparing with their age- and gender-matched healthy subjects were mainly involved in cell morphology, cellular assembly and organization, and nerve system development and function. In addition, mothers having children with ASD possessed a unique gene expression signature shown as significant alterations of protein synthesis despite of their nonautistic diagnostic status. Moreover, an ASD-associated gene expression signature was commonly observed in both individuals with ASD and healthy mothers having children with ASD.

2011-01-13 | GSE26415 | GEO

Homo sapiens

Project description:PsychENCODE Consortium: Epigenetic Dysregulation in Autism Spectrum Disorder

| PRJNA344520 | ENA

Homo sapiens

Project description:Structural Variation of Chromosomes in Autism Spectrum Disorder.

| PRJNA102819 | ENA