Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional circuits that regulate early T cell precursor acute leukemia [Hi-C]

ABSTRACT: Transcriptional circuits that regulate early T cell precursor acute leukemia [Hi-C]

PROVIDER: PRJNA987715 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25029838_1.fastq.gz	Fastqsanger.gz
	SRR25029838_2.fastq.gz	Fastqsanger.gz
	SRR25029839_1.fastq.gz	Fastqsanger.gz
	SRR25029839_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Transcriptional circuits that regulate early T cell precursor acute leukemia

Project description:Transcriptional circuits that regulate early T cell precursor acute leukemia

| PRJNA987702 | ENA

Transcriptional circuits that regulate early T cell precursor acute leukemia [HiChIP]

Project description:Transcriptional circuits that regulate early T cell precursor acute leukemia [HiChIP]

| PRJNA987714 | ENA

Transcriptional circuits that regulate early T cell precursor acute leukemia [Hi-C]

Project description:The discovery of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) was based on expression of stem cell genes that are characteristic of mouse ETP cells, the most primitive multipotent cells in the thymus. Using complementary mouse and human genetic models and genome-wide expression and chromatin profiling integrated with 3D chromatin mapping, we show that the PIAS-like coactivator ZMIZ1 promotes immature T-ALL proliferation by recruiting the transcription factor MYB in feedforward circuits to cooperatively induce MYCN, MEF2C, and BCL2, which were recently associated with the high-risk bone marrow progenitor (BMP-like) subset.

2023-07-03 | GSE235846 | GEO

Transcriptional circuits that regulate early T cell precursor acute leukemia (RNA-seq)

Project description:Transcriptional circuits that regulate early T cell precursor acute leukemia (RNA-seq)

| PRJNA986903 | ENA

Transcriptional circuits that regulate early T cell precursor acute leukemia [HiChIP]

2023-07-03 | GSE235847 | GEO

Transcriptional circuits that regulate early T cell precursor acute leukemia (RNA-seq)

2023-07-05 | GSE235685 | GEO

Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits

Project description:Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits

| PRJNA510932 | ENA

Transcriptional circuits that regulate early T cell precursor acute leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-03 | GSE235848 | GEO

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

Project description:Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

| PRJNA491753 | ENA

Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits

Project description:Various species of non-coding RNAs (ncRNAs) are enriched in subcellular compartments but the mechanisms orchestrating their localization and their local functions remain largely unknown. We investigated both aspects using the elongating retinal ganglion cell axon and its tip, the growth cone, as models. We reveal that specific endogenous precursor microRNAs (pre-miRNAs) are actively trafficked to distal axons by hitchhiking primarily on late endosomes / lysosomes. Upon exposure to Sema3A, pre-miRNAs are processed specifically within axons into newly generated miRNAs, one of which, in turn, silences the basal translation of tubulin beta 3 class III (TUBB3) but not amyloid beta precursor protein (APP). At the organismal level, these mature miRNAs are required for growth cone steering and a fully functional visual system. Overall, our results uncover a novel mode of ncRNA transport from one cytosolic compartment to another within polarized cells. They also reveal that newly generated miRNAs are critical components of a ncRNA-based signaling pathway that transduces environmental signals into the structural remodelling of subcellular compartments.

2020-02-10 | GSE124168 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data