Project description:The human microbiota is believed to influence health. Microbiome dysbiosis may be linked to neurological conditions like Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). We report the ability of a probiotic bacterial strain in halting neurodegeneration phenotypes. We show that Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of ALS and HD. Our results show that neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains, and resides in its fatty acid content. Neuroprotection by L. rhamnosus HA-114 requires acdh-1/ACADSB, kat-1/ACAT1 and elo-6/ELOVL3/6, which are key fatty acid metabolism and mitochondrial b-oxidation genes. Our data suggest that disrupted lipid metabolism contributes to neurodegeneration and that dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial b-oxidation. L. rhamnosus HA-114 is suitable for human consumption opening the possibility of modifying disease progression by dietary intervention.

2021-12-05 | GSE189988 | GEO

Lacticaseibacillus rhamnosus strain:VHProbi M14

Project description:Lacticaseibacillus rhamnosus M14 genome sequencing

| PRJNA824241 | ENA

Extracellular vesicles of Lacticaseibacillus rhamnosus PCM 489

Project description:Identification of proteins contained in extracellular vesicles of Lacticaseibacillus rhamnosus PCM 489. Dataset is related to publication http://dx.doi.org/10.20517/evcna.2024.49. This work was financially supported by the National Science Centre, Poland (no. 2021/43/D/NZ6/01464).

2024-11-07 | PXD048876 | Pride

Lacticaseibacillus rhamnosus strain:A20T1A

Project description:Lacticaseibacillus rhamnosus strain:A20T1A Assembly

| PRJNA1073219 | ENA

Lacticaseibacillus paracasei strain:VHProbi F11

Project description:Lacticaseibacillus paracasei VHProbi F11 genome sequencing

| PRJNA821934 | ENA

Lacticaseibacillus rhamnosus strain:M2b

Project description:Lacticaseibacillus rhamnosus strain:M2b Genome sequencing

| PRJNA1171989 | ENA