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An analysis of DNA methylome to understand the etiological mechanisms of F. nucleatum in laryngeal cancer

ABSTRACT: An analysis of DNA methylome to understand the etiological mechanisms of F. nucleatum in laryngeal cancer

PROVIDER: PRJNA989089 | ENA |

REPOSITORIES: ENA

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An analysis of DNA methylome to understand the etiological mechanisms of F. nucleatum in laryngeal cancer

Project description:After laryngeal cancer cells were cocultured with F. nucleatum, whole genome-wide methylation was analyzed using DNA methylation arrays.

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Transcriptome analysis reveals that Fusobacterium nucleatum promotes the expression of JAK3 in laryngeal cancer

Project description:We perform an analysis of transcriptome to understand the etiological mechanisms of F. nucleatum in laryngeal cancer.

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Integrative methylome and transcriptome analysis reveals that Fusobacterium nucleatum promotes the expression of JAK3 in laryngeal cancer

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Project description:Fusobacterium nucleatum (F. nucleatum) is implicated to exacerbate colorectal cancer. However, there is also evidence that the bacterium accumulates on other cancer types such as breast cancer. In order to better understand the transcriptional response of breast cancer cells to infection with F. nucleatum, we performed RNA-seq of the murine breast cancer cell AT3 with F. nucleatum.

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The effect of blood on Fusobacterium nucleatum

Project description:Fusobacterium nucleatum is a Gram-negative oral bacterial species associated with periodontal disease progression. As periodontal disease progresses, it is known F. nucleatum coaggregated with blood is frequently detected in the gingival crevice. However, it is largely unknown whether these interactions between F. nucleatum and blood induce a particular genetic response. We tested the cultures of F. nucleatum ATCC 25586 with or without blood in a semi-defined growth medium by microarray analysis and found 14 genes that were affected after only about 4hr. of adhered blood. Then, we selected 7 genes that changed significantly and tested these genes via real-time RT-PCR to confirm the validity of the microarray results. As a result, one amino sugar-binding protein on the membrane of F. nucleatum was especially expressed high via both microarray and real-time RT-PCR. Based upon these data, it appears that the protein on the F. nucleatum membrane binds and transfers the amino sugar only under blood conditions. This study aims to determine the effect of blood on the gene expression profiling of F. nucreatum. The study contains 2 separate experiments that both measure the cultures without or with blood. The samples with blood contain 9% and 33% blood.

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Project description:Fusobacterium nucleatum-treated LoVo cells reported an increased promoting CRC metastasis effect compared with PBS control. To understand the underlying mechanisms of Fusobacterium nucleatum-induced metastasis ability of CRC cells, we performed RNA-sequencing in LoVo cells s with or without Fusobacterium nucleatum treatment with three independent biological replicates.

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Transcriptome analysis reveals that Fusobacterium nucleatum promotes the expression of JAK3 in laryngeal cancer

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Fusobacterium nucleatum subsp. nucleatum

Project description:Fusobacterium nucleatum subsp. nucleatum Raw sequence reads

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Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis

Project description:Fusobacterium nucleatum-treated HCT116 cells reported an increased adhesion to endothelial cells compared with PBS control. To understand the underlying mechanisms of Fusobacterium nucleatum-induced intercellular adhesion ability of CRC cells, we performed RNA-sequencing in HCT116 cells with or without Fusobacterium nucleatum treatment with three independent biological replicates.

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