Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ambystoma mexicanum

ABSTRACT: A scATAC-seq atlas of chromatin accessibility in axolotl brain regions

PROVIDER: PRJNA990676 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25242056_1.fastq.gz	Fastqsanger.gz
	SRR25242056_2.fastq.gz	Fastqsanger.gz
	SRR25242057_1.fastq.gz	Fastqsanger.gz
	SRR25242057_2.fastq.gz	Fastqsanger.gz
	SRR25242058_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 50

Similar Datasets

Ambystoma mexicanum

Project description:Spatiotemporal reconstruction of axolotl brain development and regeneration at single-nuclei resolution

| PRJNA1066521 | ENA

Ambystoma mexicanum

Project description:Differentially expressed genes during axolotl jaw regeneration identified by RNA-seq

| PRJNA376733 | ENA

Ambystoma mexicanum

Project description:An ATAC-seq dataset uncovers the regulatory landscape during axolotl limb regeneration

| PRJNA682840 | ENA

Ambystoma mexicanum

Project description:Expression data from regenerating axolotl forelimbs

| PRJNA360578 | ENA

Ambystoma mexicanum

Project description:axolotl 10x single cell RNA Raw sequence reads

| PRJNA589484 | ENA

Ambystoma mexicanum

Project description:Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration

| PRJNA141103 | ENA

Tyrp1 is the mendelian determinant of the Axolotl (Ambystoma mexicanum) copper mutant

Project description:Several dozen Mendelian mutants have been discovered in axolotl (Ambystoma mexicanum) populations, including several that affect pigmentation. Four pigment mutants have been described in the scientific literature and genes for three of these have been identified. Here we report on copper, a Mendelian mutant with an albino-like phenotype known only from the pet trade. To identify the gene for copper, we performed a cross segregating copper and wildtype color phenotypes and used Bulked Segregant RNA-Seq to identify a region on chromosome 6 that was enriched for single-nucleotide polymorphisms (SNPs) between the color phenotypes. This region included Tyrosinase-like Protein 1 (Tyrp1), a melanin synthesis protein that when mutated, is associated with lighter than black melanin coloration in animal models and oculocutaneous albinism in humans. Inspection of RNA-Seq reads identified a single nucleotide deletion that is predicted to change the coding frame, introducing a premature stop codon in exon 6 and yield a truncated Tyrp1 protein in copper individuals. Using CRISPR-Cas9 editing, we show that wildtype Tyrp1 crispants exhibit copper pigmentation, thus confirming Tyrp1 as the copper locus. Our results suggest that commercial and hobbyist axolotl populations may harbor useful mutants for biological research.

2024-10-22 | GSE269079 | GEO

Ambystoma mexicanum

Project description:Small RNA and mRNA expression profiling during axolotl forelimb regeneration

| PRJNA299879 | ENA

Ambystoma mexicanum

Project description:Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [axolotl data]

| PRJNA292920 | ENA

Ambystoma mexicanum

Project description:Gene Expression During the First 28 Days of Axolotl Limb Regeneration

| PRJNA278991 | ENA