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P53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [PCHiC]

ABSTRACT: p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [PCHiC]

PROVIDER: PRJNA990725 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25115716_1.fastq.gz	Fastqsanger.gz
	SRR25115716_2.fastq.gz	Fastqsanger.gz
	SRR25115717_1.fastq.gz	Fastqsanger.gz
	SRR25115717_2.fastq.gz	Fastqsanger.gz
	SRR25115718_1.fastq.gz	Fastqsanger.gz

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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [PCHiC]

Project description:Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critical role of spatio-temporal genome architecture in this process. We demonstrate that p53 drives direct and indirect changes in genome compartments, topologically associating domains and DNA loops within minutes of its activation, which escort the p53 transcriptional program along time. Focused on p53-bound enhancers, we report a core transcriptional program of 340 genes directly regulated by p53 over distance, most of these not previously identified. Finally, we showcase that p53 controls transcription of distal genes through newly formed and pre-existing enhancer-promoter loops in a cohesin dependent manner. Taken together, our findings demonstrate a previously unappreciated architectural role of p53 as regulator at distinct topological layers and provide a reliable set of new p53 direct target genes that may help future designs of p53-based cancer therapies.

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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-17 | GSE235947 | GEO

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med-pchic-dac

Project description:The data are accessible under the terms of the following Data Access Agreement that needs to be filled in, signed (by yourself and your institutional official contact) and returned by email to this address: med-pchic-dac@lists.cam.ac.uk

| EGAC00001000523 | EGA

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