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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

ABSTRACT: TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

PROVIDER: PRJNA990741 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25119002_1.fastq.gz	Fastqsanger.gz
	SRR25119002_2.fastq.gz	Fastqsanger.gz
	SRR25119003_1.fastq.gz	Fastqsanger.gz
	SRR25119003_2.fastq.gz	Fastqsanger.gz
	SRR25119004_1.fastq.gz	Fastqsanger.gz

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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

Project description:Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylated modifier TET1 can affect the expressions of key oncogenes or tumor suppressor genes, thus contributing to tumor formation. Nonetheless, how TET1 affects the progression of cervical cancer is yet to be elucidated. In this study, we found that the expression of TET1 was significantly downregulated in cervical cancer tissues. Functionally, TET1 knockdown in cervical cancer cells can promote cell proliferation, migration, invasion, cervical xenograft tumor formation and EMT. On the contrary, its overexpression can reverse the aforementioned processes. Moreover, the autophagy level of cervical cancer cells can be enhanced after TET1 knockdown. Mechanistically, methylated DNA immunoprecipitation (MeDIP)-sequencing and MeDIP quantitative real-time PCR revealed that TET1 mediates the methylation of autophagy promoter regions. These findings suggest that TET1 affects the malignant biological behavior of cervical cancer cells by altering the methylation levels of autophagy genes NKRF and HIST1H2AK, but the specific mechanism needs to be investigated further.

2024-03-13 | GSE236396 | GEO

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

Project description:TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

Project description:TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

Project description:This SuperSeries is composed of the SubSeries listed below.

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Circular RNA YPEL2 promotes cell proliferation, migration and invasion as a biomaker in cervical cancer

Project description:Circular RNA YPEL2 promotes cell proliferation, migration and invasion as a biomaker in cervical cancer

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MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression

Project description:MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, the mechanisms underlying their actions in cervical cancer remain unclear. The present study aimed to evaluate the functional role of miR‑130a‑3p in cervical cancer. Cervical cancer cells were transfected with a miRNA inhibitor (anti‑miR‑130a‑3p) and a negative control. Adhesion‑independent cell proliferation, migration and invasion were evaluated. The findings presented herein demonstrated that miR‑130a‑3p was overexpressed in HeLa, SiHa, CaSki, C‑4I and HCB‑514 cervical cancer cells. The inhibition of miR‑130a‑3p significantly reduced the proliferation, migration and invasion of cervical cancer cells. The canonical delta‑like Notch1 ligand (DLL1) was identified as a possible direct target of miR‑103a‑3p. The DLL1 gene was further found to be significantly downregulated in cervical cancer tissues. On the whole, the present study demonstrates that miR‑130a‑3p contributes to the proliferation, migration and invasion of cervical cancer cells. Therefore, miR‑130a‑3p may be used as a biomarker to determine cervical cancer progression.

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