Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Homogeneity of recurrent vulvovaginal isolate diversity from vaginal and rectal Candida populations

PROVIDER: PRJNA991137 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25130058_1.fastq.gz	Fastqsanger.gz
	SRR25130058_2.fastq.gz	Fastqsanger.gz
	SRR25130059_1.fastq.gz	Fastqsanger.gz
	SRR25130059_2.fastq.gz	Fastqsanger.gz
	SRR25130060_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

Project description:Diversity of vaginal microbiome during recurrent vulvovaginal candidiasis

| PRJNA850781 | ENA

Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome

Project description:RNA-seq analysis of an in vivo murine model of vulvovaginal candidiasis Murine vaginas were infected with Candida albicans and harvested for RNA-seq analysis 3 days post-infection

2015-04-11 | E-GEOD-67688 | biostudies-arrayexpress

Homo sapiens

Project description:Recurrent vulvovaginal candidiasis: a dynamic interkingdom biofilm disease of Candida and Lactobacillus

| PRJNA719953 | ENA

Ex vivo effects of Tenofovir on four vaginal epithelial cell lines

Project description:In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (15 subjects/arm). Experiments were repeated using primary vaginal epithelial cells from four healthy women. 36 Arrays (3 primary vaginal epithelial cell lines from healthy women donors, cultured with or without 50uM or 500 uM Tenofovir for 1,4,7, or 14 days per donor cell line. A no treatment, culture media only control was included for each donor cell line and for each time point.

2015-02-23 | E-GEOD-57026 | biostudies-arrayexpress

Ex vivo effects of Tenofovir on four vaginal epithelial cell lines

2015-02-23 | GSE57026 | GEO

Systems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial

2015-02-23 | GSE57025 | GEO

Project description:Rectal and Vaginal Microbiota

| PRJNA884021 | ENA

Project description:Fluconazole use on the vaginal and gut fungal and bacterial microbiomes in Recurrent Vulvovaginal Candidiasis (RVVC)

| PRJNA1107283 | ENA

Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in humans and increases susceptibility to HIV-1 in humanized mice

Project description:The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and is associated with increased HIV-1 acquisition. However, the effect of MPA on diversity of the vaginal microbiota is relatively unknown. In a cohort of female Kenyan sex workers, negative for sexually transmitted infections (STIs), with Nugent scores <7 (N=58 of 370 screened), MPA correlated with significantly increased diversity of the vaginal microbiota as assessed by 16S rRNA gene sequencing. MPA was also significantly associated with decreased levels of estrogen in the plasma, and low vaginal glycogen and α-amylase, factors implicated in vaginal colonization by lactobacilli, bacteria that are believed to protect against STIs. In a humanized mouse model, MPA treatment was associated with low serum estrogen, low glycogen and enhanced HIV-1 susceptibility. The mechanism by which the MPA mediated changes in the vaginal microbiota may contribute to HIV-1 susceptibility in humans appears to be independent of inflammatory cytokines and/or activated T cells. Altogether, these results suggest MPA-induced hypo-estrogenism may alter key metabolic components that are necessary for vaginal colonization by certain bacterial species including lactobacilli, and allow for greater bacterial diversity in the vaginal microbiota.

2019-10-17 | GSE138971 | GEO

Project description:Candida glabrata-associated vulvovaginal candidiasis: a pilot study of vaginal microbiota patterns in Mexican women

| PRJNA1199545 | ENA