Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CDK12 prevents MYC-induced transcription-replication conflicts [EU-seq]

ABSTRACT: CDK12 prevents MYC-induced transcription-replication conflicts [EU-seq]

PROVIDER: PRJNA991554 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25152737_1.fastq.gz	Fastqsanger.gz
	SRR25152737_2.fastq.gz	Fastqsanger.gz
	SRR25152738_1.fastq.gz	Fastqsanger.gz
	SRR25152738_2.fastq.gz	Fastqsanger.gz
	SRR25152739_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

CDK12 prevents MYC-induced transcription-replication conflicts [EU-seq]

Project description:In order to identify genes and pathways necessary to preserve genome integrity upon Myc over-expression, we conducted a large siRNA-based screen in isogenic lines. We discovered several genes that suppressed the Myc-induced DNA-damage response and that were essential for the cell survival upon Myc activation. We idntified CDK12, a cyclin dependent kinase involved in transcriptional control and genome stability. We uncovered a novel and unexpected role of CDK12 in controlling transcription at loci proximal to DNA damaged sites and dissected its upstream regulatory pathways and downstream effectors. Mechanistic studies and genome-wide mapping of replication dynamics and DSBs revealed how CDK12 is essential to suppress intrinsic transcription-replication conflicts, thus avoiding cytotoxic DNA damage in cancer cells. Overall, this study uncovers a novel role for CDK12 and a new liability of Myc-driven cancers, which could be exploited for therapeutic purposes.

2024-06-19 | GSE236549 | GEO

CDK12 prevents MYC-induced transcription-replication conflicts

Project description:CDK12 prevents MYC-induced transcription-replication conflicts

| PRJNA991561 | ENA

CDK12 prevents MYC-induced transcription-replication conflicts [BLISS]

Project description:CDK12 prevents MYC-induced transcription-replication conflicts [BLISS]

| PRJNA991555 | ENA