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Ageing related deficiency of miR-708-5p in osteoarthritic cartilage lesions [miRNA]

ABSTRACT: Ageing related deficiency of miR-708-5p in osteoarthritic cartilage lesions [miRNA]

PROVIDER: PRJNA993238 | ENA |

REPOSITORIES: ENA

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Project description:Aging is a major risk factors for osteoarthritis (OA), and cartilage of the elder are more sensitive to mechanical loading stress. Recently, cartilage progenitor cells (CPCs) arose much interests due to its important role in maintaining cartilage homeostasis. However, the potential mechanism of increased sensitivity to mechanical stress in CPCs has not been elucidated. The aim of this study was to investigate the potential links between aging and age-related OA through establish CPCs replicative senescence model and fluid flow shear stress (FFSS) stimulated degeneration model. Small RNA and mRNA sequence were conducted to investigate miRNA-related mechanisms in this process. By gain-and-lost strategy we investigated the age-related miRNAs and their impacts on exacerbating the progression of biomechanical stimulated TMJ-OA. miR-708-5p was identified as age-related miRNA in CPCs, and TLR4 was identified as its direct target through luciferase report assay. Age-related miR-708-5p deficiency increased sensitivity of CPCs for exposure to FFSS by liberating TLR4 expression. Intra-articular delivery agomiR-708-5p alleviated TMJ osteoarthritic cartilage lesions in mice. In conclusion, age-related miR-708-5p deficiency increases the sensitivity to mechanical loading stress and promotes CPCs senescence like degeneration via TLR4.

2023-07-11 | GSE236978 | GEO

2023-07-11 | GSE236977 | GEO

Project description:Ageing related deficiency of miR-708-5p in osteoarthritic cartilage lesions

| PRJNA993237 | ENA

Project description:Ageing related deficiency of miR-708-5p in osteoarthritic cartilage lesions [RNA]

| PRJNA993239 | ENA

Project description:This SuperSeries is composed of the SubSeries listed below.

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Transcriptomic signatures of cartilage ageing

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Transcriptomic signatures of cartilage ageing

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Stress-regulated miR-708-5p affects recognition memory and manic-like behavior through Neuronatin downregulation.

Project description:microRNAs are posttranscriptional regulators that bind to target mRNAs. We tested the regulatory effect of miR-708-5p, a miRNA associated with Bipolar Disorder, in the mouse hippocampus. To unveil molecular mechanisms downstream of miR-708-5p, we stereotactically injected a virus overexpressing miR-708-5p for target discovery.

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