Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: Stonewalling Drosophila stem cell differentiation by epigenetic controls

OTHER RELATED OMICS DATASETS IN: E-GEOD-6928

PROVIDER: PRJNA99355 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Drosophila melanogaster

Project description:Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

| PRJNA379553 | ENA

Drosophila melanogaster

Project description:The Hox gene Abd-B controls stem cell niche function in the Drosophila testis

| PRJNA232693 | ENA

Drosophila melanogaster

Project description:Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

| PRJNA686687 | ENA

Drosophila melanogaster

Project description:Peroxisome elevation induces stem cell differentiation and intestinal epithelial repair

| PRJNA563469 | ENA

Drosophila melanogaster

Project description:Tis11 mediated mRNA degradation regulates intestinal stem cell quiescence in Drosophila melanogaster

| PRJNA381000 | ENA

Drosophila melanogaster

Project description:Drosophila melanogaster RNA-seq of Nicknack knockouts and controls

| PRJNA643855 | ENA

Drosophila melanogaster

Project description:ClC-c regulates intestinal stem cell proliferation via EGFR signaling pathway in Drosophila

| PRJNA748595 | ENA

Drosophila melanogaster

Project description:Histone turnover mediates epigenetic processes in Drosophila S2 cells

| PRJNA95249 | ENA

Drosophila melanogaster

Project description:Drosophila melanogaster transcriptional profiling over life span: Indy vs. Controls

| PRJNA110479 | ENA

Multigenerational effect of heat stress on the Drosophila melanogaster sperm proteome

Project description:The notion that genes are the sole units of heredity and that a barrier exists between soma and germline has been a major hurdle in elucidating the heritability of traits that were observed to follow a non-Mendelian inheritance pattern. It was only after the conception of “epigenetics” by C. H. Waddington that the effect of parental environment on subsequent generations via non-DNA sequence-based mechanisms, such as DNA methylation, chromatin modifications, non-coding RNAs and proteins, could be established in various organisms, now referred to as multigenerational epigenetic inheritance. Despite the growing body of evidence, the male gamete-derived epigenetic factors that mediate the transmission of such phenotypes are seldom explored, particularly in the model organism Drosophila melanogaster. Using the heat stress-induced multigenerational epigenetic inheritance paradigm in a widely used position-effect variegation line of Drosophila, named white-mottled, we have dissected the effect of heat stress on the sperm proteome in the current study. We demonstrate that multiple successive generations of heat stress at the early embryonic stage results in a significant downregulation of proteins associated with translation, chromatin organization, microtubule-based processes, and generation of metabolites and energy in the Drosophila sperms. Based on our findings, we propose chromatin-based epigenetic mechanisms, a well-established mechanism for environmentally induced multigenerational effects, as a plausible way of transmitting heat stress memory via the male germ line in subsequent generations. Moreover, we demonstrate the effect of multiple generations of heat stress on the reproductive fitness of Drosophila, shedding light on the adaptive or maladaptive potential of heat stress-induced multigenerational phenotypes.

2024-05-10 | PXD037488 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data