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Mutations from IPEX patients elicit a range of phenotypes in mice [scATAC-Seq]

ABSTRACT: Mutations from IPEX patients elicit a range of phenotypes in mice [scATAC-Seq]

PROVIDER: PRJNA994157 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25249749_1.fastq.gz	Fastqsanger.gz
	SRR25249749_2.fastq.gz	Fastqsanger.gz

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Mutations from IPEX patients elicit a range of phenotypes in mice

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Mutations from IPEX patients elicit a range of phenotypes in mice [scATAC-Seq]

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Mutations from IPEX patients elicit a range of phenotypes in mice

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Single-cell RNAseq (10x Genomics) analysis of human CD4+ T cells in IPEX patients, healthy donors and heterozygous mothers (blood).

Project description:Single-cell RNAseq (10x Genomics) analysis of human CD4+ T cells in IPEX patients, healthy donors and heterozygous mothers (blood). Human CD4+T cells from IPEX, HD and mothers were isolated from frozen peripheral blood mononuclear cells by flow cytometry as DAPI–CD3+CD4+ cells. In cohort 1, cells from separate donor were encapsulated in separate channel following 10x Genomics Single Cell 3′ Reagent Kit (V2 chemistry). In cohort 2, samples were tagged using a different Hashtags, pooled and encapsulared following 10x Genomics Single Cell 3′ Reagent Kit (V3 chemistry).

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