Project description:Angiotensin I-converting enzyme (ACE) plays a vital role in cardiovascular disease (CVD). Natural ACE inhibitory peptides from Ganoderma lingzhi (G. lingzhi) showed potential vasodilatation in vitro or in vivo. Recent studies have shown that long non-coding (lncRNA) plays critical roles in biological processes and human diseases, since the roles of lncRNA in CVD remain unclear. Our findings indicate that the expression profiles of lncRNAs has changed in spontaneously hypertensive rats (SHRs) treated by the G. lingzhi peptide, compared with untreatedt groups. It is expected to provide novel insight into the underlying molecular mechanism and potential targets for hypertention therapy.
Project description:The golden genome annotation of Ganoderma lingzhi reveals a more complex scenario of eukaryotic gene structure and transcription activity
