Project description:We reported the side-effects of High fat diet & STZ on the cecum, and found that the AOS10-FMT could rescure the side-effect of High fat diet & STZ in many factors
Project description:Gene expression for genes differentially expressed between early vs. late tumor onset and high fat diet (HFD) vs. low fat diet (LFD) in P53 -/- mice. 4 HFD early tumor onset, 7 HFD late tumor onset, 4 HFD to LFD switch with early tumor onset, 6 HFD to LFD switch with late tumor onset, 4 LFD early tumor onset, 7 LFD late tumor onset, 5 LFD to HFD switch with early tumor onset, 4 LFD to HFD switch with late tumor onset
Project description:Chronic exposure to inorganic arsenic (iAs) or a high-fat diet (HFD) can produce liver injury. However, the interactive molecular biological effects and mechanism of iAs and HFD are as of yet unclear. We used microarrays to detail the interactive effects of arsenic and a high-fat diet on hepatic gene expression. The C57BL/6 Mice fed low-fat diet (LFD) or HFD were exposed to 3 mg/L iAs or deionized water for 10 weeks. Then, hepatic RNA were extraction and hybridization on Affymetrix microarrays. Differentially expressed genes in LFD+As, HFD, and HFD+As groups compared to LFD group were identified, and interactive molecular biological effects and mechanism of iAs and HFD were discussed.