Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Polyanion binding proteins data for five cellular polyanionic samples

ABSTRACT: Polyanion binding proteins data for five cellular polyanionic samples

PROVIDER: PRJNA99647 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Polyanion binding proteins data for five cellular polyanionic samples

Project description:The existence of interactions between many cellular proteins and various polyanionic surfaces within a cell is now well-established. The functional role of such interactions, however, remains to be clearly defined. The existence of protein arrays, with a large selection of different kinds of proteins, provides a way to better address a number of aspects of this question. We have therefore investigated the interaction between five cellular polyanions (actin, tubulin, heparin, heparan sulfate (HS), and DNA) and approximately 5,000 human proteins using protein microarrays in an attempt to better understand the functional nature of such interaction(s). We demonstrate that a large number of polyanion binding proteins exist which contain multiply positively-charged regions, are often disordered, are involved in phosphorylation processes, and appear to play a role in protein-protein interaction networks. Considering the crowded nature of cellular interiors, we propose that polyanion binding proteins (PABPs) interact with a wide variety of polyanionic surfaces in cells in a functionally significant manner. Keywords: Protein-Protein, protein-polyanion Interaction

2006-11-30 | GSE6354 | GEO

HDCA binding proteins

Project description:HDCA binding proteins

| PRJNA1006334 | ENA

CEBPA binding in five vertebrates

Project description:CEBPA binding in five vertebrates

| PRJEB2006 | ENA

Next generation sequencing of transcripts associated to five selected RNA-binding proteins in Leishmania infantum

Project description:Next generation sequencing of transcripts associated to five selected RNA-binding proteins in Leishmania infantum

| PRJNA675759 | ENA

Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor

Project description:Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor