Ontology highlight
ABSTRACT:
PROVIDER: PRJNA997010 | ENA |
REPOSITORIES: ENA
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Project description:We evaluated AR-related effects on genome wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity, and both adaptive and innate immune function. Further, we find that differential expression of immune related genes may be attributable to AR-related effects on leukocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of AR exposure on a wild carnivore.
2018-03-25 | GSE108175 | GEO
Project description:Sublethal effects of perfluoroethylcyclohexanesulfonate (PFECHS) on the gene expression and protein activity of Daphnia magna Reference sample is a composite of equal amounts of total RNA (500 ng each) from n=3 culture media control
2015-12-03 | GSE75607 | GEO
Project description:Sublethal effects of the flame retardant intermediate hexachlorocyclopentadiene (HCCPD) on the gene expression and protein activity of Daphnia magna Reference sample is a composite of equal amounts of total RNA (500 ng each) from n=3 culture media controls and n=3 methanol controls Two-condition experiment: controls (methanol and cell culture) and three sublethal doses of HCCPD (0.138 ug/L, 1.38 ug/L, 13.8 ug/L). Biological replicates: 3 replicates each group.
2013-09-01 | E-GEOD-45998 | biostudies-arrayexpress
Project description:The goal of this project is to identify neural and molecular biomarkers as predictors of MeHg exposure and deficits in specific neurobehavioral endpoints. Specifically, we are investigating the effects of sublethal MeHg exposure (1, 2 and 3.5 ppm of wild-caught walleye diet) on developing zebrafish by analyzing early lifestage (ELS) toxicity, changes in global gene expression by microarray analysis and quantitative real-time PCR (QPCR), and neurobehavioral dysfunction. Gene expression analysis in exposed embryos was performed using an 8,000 element custom zebrafish cDNA microarray. Microarray results were validated using QPCR. A number of the early life stage zebrafish genes found to be dysregulated by maternal MeHg have functional annotations involving cell division, cell cycle progression, neurodevelopment, liver development, ion-binding, transcriptional regulation and endopeptidase activity.
2016-09-27 | GSE21964 | GEO
Project description:Stress preconditioning occurs when transient, sublethal stress events impact an organism's ability to counter future stresses. Although preconditioning effects are often noted in the literature, very little is known about the underlying mechanisms. To model preconditioning, we exposed a panel of genetically diverse Drosophila melanogaster to a sublethal heat shock and measured how well the flies survived exposure to endoplasmic reticulum (ER) stress. To identify genes with expression patterns predictive of preconditioning outcomes, we focused on the 10 DGRP strains at the extreme ends of our preconditioning screen. We compared the beneficial strains (RAL69, RAL93, RAL359, RAL387, RAL409) to the detrimental (RAL195, RAL304, RAL335, RAL737, RAL819) with and without heat shock (our preconditioning stress).
2023-04-25 | GSE226958 | GEO
Project description:We exposed adult delta smelt to varying levels of sublethal thermal stress to quantify the genes involved in their cellular stress response and identify sublethal stress thresholds
2015-08-25 | GSE67190 | GEO
Project description:Sublethal effects of the flame retardant intermediate hexachlorocyclopentadiene (HCCPD) on the gene expression and protein activity of Daphnia magna Reference sample is a composite of equal amounts of total RNA (500 ng each) from n=3 culture media controls and n=3 methanol controls
2013-09-01 | GSE45998 | GEO
Project description:Incomplete thermal ablation may induce invasiveness of hepatocellur carcinoma, however, the mechasim is not fully understood. Here, we investigated whether activated hepatic stellate cells would accelerate the progression of residual HCC after sublethal heat treatment via the secretion of POSTN. We used microarrays to detail the global programme of up-regulated genes of residual HCC cells induced by POSTN.
2018-01-09 | GSE108853 | GEO
Project description:Abstract Background: Faithful transcription of DNA is constantly threatened by different endogenous and environmental genotoxic effects. Transcription coupled repair has been described to quickly remove DNA lesions from the transcribed strand of active genes, permitting rapid resumption of blocked transcription. This repair mechanism has been well characterized in the past using individual target genes. However, the precise mechanism by which RNA polymerase II (Pol II) transcription is affected following UV irradiation during the repair processes genome-wide is not well understood. Results: We investigated the effect of a non-lethal dose of UVB on global DNA-bound Pol II distribution in human cells. We find that about 90% of the promoters of expressed genes show reduced Pol II occupancy 2-4 hours following UVB irradiation, and that the presence of Pol II is restored to “normal”, or higher, levels 5-6 hours after irradiation. We also identified a smaller set of genes, where the presence of Pol II at the promoter regions does not decrease after UVB irradiation, but often increases throughout the entire transcription units. Interestingly, at promoters, where Pol II promoter clearance occurs, TFIIH but not TBP follows the behavior of Pol II suggesting that at these genes TFIIH may be sequestered for DNA repair upon UVB treatment. Conclusions: Thus, our study reveals a global negative regulatory mechanism that targets Pol II transcription initiation on the large majority of transcribed genes following sublethal UVB irradiation, and a small subset of genes (including regulators of repair, cell growth and survival), where Pol II escapes this negative regulation. Following genome-wide RNA Polymerase II redistribution over time upon UVB irradiation
2014-07-25 | E-GEOD-52789 | biostudies-arrayexpress