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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

ABSTRACT: The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

PROVIDER: PRJNA997356 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25388317.fastq.gz	Fastqsanger.gz
	SRR25388318.fastq.gz	Fastqsanger.gz
	SRR25388319.fastq.gz	Fastqsanger.gz
	SRR25388320.fastq.gz	Fastqsanger.gz
	SRR25388321.fastq.gz	Fastqsanger.gz

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

Project description:We combined mRNA, small RNA and ribosome methylation sequencing to investigate snoRNA expression patterns in multiple myeloma and their association with different chromosomal aberrations. We identified snoRNAs dysregulated in molecular subgroups, with SNORD78 being highly expressed in gain1q patients and associated with poor prognosis. Our study shows that the expression of particular snoRNAs and methylation of specific snoRNA-guided rRNA sites are associated with specific chromosome gains, which are common elements in multiple myeloma.

2023-10-16 | GSE237998 | GEO

The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations

Project description:The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

Project description:The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

Project description:We combined mRNA, small RNA and ribosome 2'O-methylation sequencing to investigate snoRNA expression patterns in multiple myeloma and their association with different chromosomal aberrations. We identified snoRNAs dysregulated in molecular subgroups, with SNORD78 being highly expressed in gain1q patients and associated with poor prognosis. Our study shows that the expression of particular snoRNAs and methylation of specific snoRNA-guided rRNA sites are associated with specific chromosome gains, which are common elements in multiple myeloma.

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations.

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NUCLEAR FATE OF YEAST SNORNA IS DETERMINED BY COTRANSCRIPTIONAL RNT1 CLEAVAGE

Project description:We show that in S. cerevisiae pre-snoRNA processing by the endonuclease Rnt1 occurs co-transcriptionally, removing the m7G cap to facilitate the formation of box C/D snoRNA. Failure to remove m7G cap from box C/D pre-snoRNA affects 3’ end processing, ribonucleoprotein complex formation and causes mislocalization to the cytoplasm. Consequently, Rnt1-dependent 5’ end processing of box C/D snoRNA is critical for snoRNA-dependent methylation of ribosomal RNA. Our results reveal that the 5’ end processing defines a distinct pathway for snoRNA maturation.

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Project description:Small nucleolar RNAs (snoRNA) are non-coding RNAs known for guiding RNA modifications including 2ʹ-O-methylation (Nm) and pseudouridine (Ψ). While snoRNAs may also interact with other RNAs such as mRNA, the full repertoire of RNAs targeted by snoRNA remains elusive due to the lack of effective technologies that identify snoRNA targets transcriptome-wide. Here we develop a chemical crosslinking-based approach that comprehensively detects cellular RNA targets of snoRNAs, yielding thousands of previously unrecognized snoRNA-mRNA interactions in human cells and mouse brain tissues. Many interactions occur outside of snoRNA-guided rRNA modification sites, hinting at non-canonical functions beyond RNA modification. We find that one of these snoRNAs, SNORA73, targets mRNAs that encode secretory proteins and membrane proteins. SNORA73 also interacts with 7SL RNA, part of the signal recognition particle (SRP) required for protein secretion. The mRNA-SNORA73-7SL RNA interactions enhance the association of the SNORA73-target mRNAs with SRP, thereby facilitating secretion of the encoded proteins.

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