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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

ABSTRACT: The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

PROVIDER: PRJNA997357 | ENA |

REPOSITORIES: ENA

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations

Project description:The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations

| PRJNA997355 | ENA

The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

Project description:The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (RibomethSeq)

Project description:We combined mRNA, small RNA and ribosome 2'O-methylation sequencing to investigate snoRNA expression patterns in multiple myeloma and their association with different chromosomal aberrations. We identified snoRNAs dysregulated in molecular subgroups, with SNORD78 being highly expressed in gain1q patients and associated with poor prognosis. Our study shows that the expression of particular snoRNAs and methylation of specific snoRNA-guided rRNA sites are associated with specific chromosome gains, which are common elements in multiple myeloma.

2023-10-16 | GSE237997 | GEO

The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations (snoRNA)

Project description:We combined mRNA, small RNA and ribosome methylation sequencing to investigate snoRNA expression patterns in multiple myeloma and their association with different chromosomal aberrations. We identified snoRNAs dysregulated in molecular subgroups, with SNORD78 being highly expressed in gain1q patients and associated with poor prognosis. Our study shows that the expression of particular snoRNAs and methylation of specific snoRNA-guided rRNA sites are associated with specific chromosome gains, which are common elements in multiple myeloma.

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Human RiboMethSeq

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations.

Project description: Not available

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Predict cytogenetic abnormalities with gene expression profiles

Project description:Cytogenetic abnormalities (CA) are important clinical parameters in various types of cancer, including multiple myeloma (MM). We developed a model to predict CA in patients with MM using gene expression profiling (GEP) and validated it by different cytogenetic techniques. The model was shown to have an accuracy up to 0.89. These results provide proof of concept for the hypothesis that GEP could serve as a one-stop data source for clinical molecular diagnosis and/or prognosis.

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The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations

Project description:This SuperSeries is composed of the SubSeries listed below.

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