Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inhalable textile microplastic fibers impair airway epithelial differentiation

ABSTRACT: Inhalable textile microplastic fibers impair airway epithelial differentiation

PROVIDER: PRJNA997907 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25396354_1.fastq.gz	Fastqsanger.gz
	SRR25396354_2.fastq.gz	Fastqsanger.gz
	SRR25396355_1.fastq.gz	Fastqsanger.gz
	SRR25396355_2.fastq.gz	Fastqsanger.gz
	SRR25396356_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Inhalable textile microplastic fibers impair airway epithelial differentiation

Project description:Rationale Microplastics are a pressing global concern and inhalation of microplastic fibers has been associated with interstitial and bronchial inflammation in flock workers. However, how microplastic fibers affect the lungs is unknown. Objectives Our aim was to assess the effects of 12x31 µm nylon 6,6 (nylon) and 15x52 µm polyethylene terephthalate (polyester) textile microplastic fibers on lung epithelial growth and differentiation. Methods We used human and murine alveolar and airway-type organoids as well as air-liquid interface cultures derived from primary lung epithelial progenitor cells and incubated these with either nylon or polyester fibers or nylon leachate. In addition, mice received one dose of nylon fibers or nylon leachate and 7 days later organoid-forming capacity of isolated epithelial cells was investigated. Results We observed that nylon microfibers, more than polyester, inhibited developing airway organoids and not established ones. This effect was mediated by components leaching from nylon. Epithelial cells isolated from mice exposed to nylon fibers or leachate, also formed fewer airway organoids, suggesting long-lasting effects of nylon components on epithelial cells. Part of these effects were recapitulated in human air-liquid interface cultures. Transcriptome analysis revealed upregulation of Hoxa5 post-exposure to nylon fibers. Inhibiting Hoxa5 protein during nylon exposure restored airway organoid formation, confirming Hoxa5's pivotal role in the effects of nylon. Conclusions These results suggest that components leaching from nylon 6,6 may especially harm developing airways and/or airways undergoing repair and we strongly encourage to characterize both hazard of and exposure to microplastic fibers in more detail.

2023-12-31 | GSE238065 | GEO

Conus textile

Project description:Conus textile overview

| PRJNA1167823 | ENA

Microplastic

Project description:Microplastic Metagenome

| PRJNA1168257 | ENA

Textile metagenome

Project description:Textile metagenome Raw sequence reads

| PRJNA735862 | ENA

Conus textile

Project description:Conus textile Raw sequence reads

| PRJNA1082045 | ENA

Combining Untargeted and Targeted Proteomic Strategies for Discrimination and Quantification of Cashmere Fibers

Project description:Cashmere is regarded as a specialty and luxury ﬁber due to its scarcity and high economic value. For fiber quality assessment, it is technically very challenging to distinguish and quantify the cashmere fiber from yak or wool fibers because of their highly similar physical appearance and substantial protein sequence homology. To address this issue, we propose a workflow combining untargeted and targeted proteomics strategies for selecting, verifying and quantifying biomarkers for cashmere textile authentication. Untargeted proteomic surveys were first applied to identify 174, 157, and 156 proteins from cashmere, wool and yak fibers respectively. After marker selection at different levels, peptides turned out to afford much higher selectivity than proteins for fiber species discrimination. Collective use of these peptide makers allowed us to discriminate and quantify cashmere fibers in commercial finished fabrics that have undergone heavy chemical treatments. Cashmere proportion measurement in fabric samples using our proteomic approach was in good agreement with results from traditional light microscopy, yet our method can be more readily standardized to become an objective and robust assay for assessing authenticity of fibers and textiles.

2018-10-25 | PXD003107 | Pride

Interaction between microplastic and drought

Project description:Response of soil fungi to the interactive effects of microplastic fibers addition and drought

| PRJEB56344 | ENA

on-site biocomplex textile

Project description:on-site biocomplex textile Metagenome

| PRJNA419840 | ENA

Wastewater microplastic microbiome

Project description:Wastewater microplastic microbiome characterization

| PRJNA638613 | ENA

Paratapes textilis breed:textile venus clam

Project description:Transcriptome sequencing of Paphia textile