Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [microC]

ABSTRACT: Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [microC]

PROVIDER: PRJNA998459 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

| PRJNA998455 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [CUT&TAG]

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [CUT&TAG]

| PRJNA998462 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [scRNA-seq]

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [scRNA-seq]

| PRJNA998460 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [Ribo-seq]

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [Ribo-seq]

| PRJNA998457 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [factory RNA-seq]

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [factory RNA-seq]

| PRJNA998461 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [bulk RNA-seq]

Project description:Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [bulk RNA-seq]

| PRJNA998463 | ENA

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [microC]

Project description:Cellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce senescence to human primary cells. Within six days of treatment with ICM, senescence hallmarks, including the nuclear eviction of HMGB1 and -B2, are uniformly induced across the cell population. By comparing various high throughput datasets from ICM-induced and replicative senescence, we uncovered significant similarities between the two states. Notably, ICM suppresses the proinflammatory secretome associated with senescence, thus alleviating most paracrine effects. In summary, ICM rapidly and synchronously induces a senescence-like phenotype that allows us to study its core regulatory program without any confounding heterogeneity.

2024-04-24 | GSE238250 | GEO