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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Supported Employment to Create a Community Culture of Rapid Testing Among People Who Inject Drugs: PeerConnect2Test

ABSTRACT: Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Supported Employment to Create a Community Culture of Rapid Testing Among People Who Inject Drugs: PeerConnect2Test

PROVIDER: PRJNA998998 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Supported Employment to Create a Community Culture of Rapid Testing Among People Who Inject Drugs: PeerConnect2Test

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Supported Employment to Create a Community Culture of Rapid Testing Among People Who Inject Drugs: PeerConnect2Test

| PRJNA998999 | ENA

Rapid Assay of Individual Microbiome responses to drugs part1

Project description:We developed an approach named Rapid Assay of Individual Microbiome (RapidAIM) to screen xenobiotics against individual microbiomes, and conducted a proof-of-concept (POC) study on the use of RapidAIM. We tested 43 compounds against five individual microbiomes. The individual microbiomes are cultured in 96-well plates for 24 hours and the samples are then analyzed using a metaproteomics-based analytical approach to gain functional insight into the individual microbiomes responses following drug treatments.The tested compounds significantly affected overall microbiome abundance, microbiome composition and functional pathways at multiple taxonomic levels. The microbiome responses to berberine, metformin, diclofenac, fructooligosaccharide and most antibiotics were consistent among most individual microbiomes. Interestingly, most of our tested NSAIDs, statins, and histamine-2 blockers induced individually distinct responses. Our workflow offers an effective solution to systematically study the effects of many different compounds on individual microbiomes.

2020-05-26 | PXD012724 | Pride

Rapid Assay of Individual Microbiome responses to drugs data part2

Project description:We developed an approach named Rapid Assay of Individual Microbiome (RapidAIM) to screen xenobiotics against individual microbiomes. To evaluate technical reproducibility, we tested 43 compounds against an individual's microbiome. The individual microbiome is cultured in triplicates in 96-well plates for 24 hours and the samples are then analyzed using a metaproteomics-based analytical approach to gain functional insight into the individual microbiomes responses following drug treatments.The tested compounds significantly affected overall microbiome abundance, microbiome composition and functional pathways at multiple taxonomic levels. The microbiome responses to berberine, metformin, diclofenac, fructooligosaccharide and most antibiotics were consistent among most individual microbiomes. Interestingly, most of our tested NSAIDs, statins, and histamine-2 blockers induced individually distinct responses. Our workflow offers an effective solution to systematically study the effects of many different compounds on individual microbiomes.

2020-05-27 | PXD012725 | Pride

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Rapid Optimization of COVID-19 Testing for People Affected by Diabetes

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Rapid Optimization of COVID-19 Testing for People Affected by Diabetes

| PRJNA1001524 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Rapid Optimization of COVID-19 Testing for People Affected by Diabetes

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Rapid Optimization of COVID-19 Testing for People Affected by Diabetes

| PRJNA1001523 | ENA

Epithelial relay of microbial signals coordinates intestinal macrophage supported barrier repair

Project description:Epithelial relay of microbial signals coordinates intestinal macrophage supported barrier repair

| PRJNA1084862 | ENA

Cannabidiol as a Harm Reduction Strategy for People Who Use Drugs: A Rapid Review.

Project description:ObjectiveThe drug poisoning crisis throughout North America necessitates novel harm reduction approaches. Emerging evidence suggests that cannabidiol (CBD) may have some utility as a harm reduction modality for those with problematic substance use. This rapid review aimed to synthesize available evidence on CBD as a potential harm reduction tool for people who use drugs while providing clinical and research insights.MethodA systematic search in EMBASE, MEDLINE, CENTRAL, and CINAHL was completed in July 2022. For inclusion, studies had to meet the following criteria: (1) drawn from an adult population of people who use drugs; (2) investigates CBD as an intervention for problematic substance use or harm reduction-related outcomes; (3) be published after the year 2000 and in English; and (4) be primary research or a review article. A narrative synthesis was used to group outcomes relevant to harm reduction and provide clinical and research insights.ResultsWe screened 3,134 records, of which 27 studies (5 randomized trials) were included. The evidence remains limited, but available studies support the potential utility of CBD to reduce drug-induced craving and anxiety in opioid use disorder. There were low-quality studies suggesting that CBD may improve mood and general well-being of people who use drugs. Evidence suggests that CBD monotherapy may not be an adequate harm reduction strategy for problematic substance use but rather an adjunct to the standard of care.ConclusionLow-quality evidence suggests that CBD may reduce drug cravings and other addiction-related symptoms and that CBD may have utility as an adjunct harm reduction strategy for people who use drugs. However, there is a significant need for more research that accurately reflects CBD dosing and administration regimens used in a real-world context.

| S-EPMC10411365 | biostudies-literature

biofilm in a PCL supported constructed wetland with limitation areation

Project description:biofilm in a PCL supported constructed wetland with limitation areation Raw sequence reads

| PRJNA763080 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-driven Optimization of COVID-19 testing to Reach and Engage underserved Areas for Testing Equity (CO-CREATE)

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-driven Optimization of COVID-19 testing to Reach and Engage underserved Areas for Testing Equity (CO-CREATE)

| PRJNA782735 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-driven Optimization of COVID-19 testing to Reach and Engage underserved Areas for Testing Equity (CO-CREATE)

| PRJNA782734 | ENA